Mus musculus Gene: Me2
Summary
InnateDB Gene IDBG-157644.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Me2
Gene Name malic enzyme 2, NAD(+)-dependent, mitochondrial
Synonyms AW120568; D030040L20Rik; NAD-ME;
Species Mus musculus
Ensembl Gene ENSMUSG00000024556
Encoded Proteins
malic enzyme 2, NAD(+)-dependent, mitochondrial
Protein Structure
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000082212:
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:73770040-73815392
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000025439 ENSMUSP00000025439
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0008948 oxaloacetate decarboxylase activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006108 malate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Pyruvate metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Pyruvate metabolism pathway
INOH
Glycolysis Gluconeogenesis pathway
Pyruvate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q99KE1
TrEMBL Q3V2Y4
UniProt Splice Variant
Entrez Gene 107029
UniGene Mm.407144 Mm.481432
RefSeq NM_145494 XM_006525496
OMIM
CCDS CCDS29339
HPRD
IMGT
MGI ID MGI:2147351
MGI Symbol Me2
EMBL AK042289 AK050933 AK050980 AK080403 AK156403 AK171157 BC004709
GenPept AAH04709 BAC31216 BAC34467 BAC34483 BAE33701 BAE42281 BAE43371
ImmGen Me2 (murine)
RNA Seq Atlas 107029