Mus musculus Gene: Me2

Summary
InnateDB Gene IDBG-157644.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol Me2
Gene Name malic enzyme 2, NAD(+)-dependent, mitochondrial
Synonyms AW120568; D030040L20Rik; NAD-ME
Species Mus musculus
Ensembl Gene ENSMUSG00000024556
Encoded Proteins
IDBP-157646 malic enzyme 2, NAD(+)-dependent, mitochondrial
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000082212:
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 18: 73770040-73815392
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000025439  ENSMUSP00000025439
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
 
Predicted by orthology
Total 5 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016619 malate dehydrogenase (oxaloacetate-decarboxylating) activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006108 malate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSG00000082212 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000016269 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
mmu00620  Pyruvate metabolism
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00620  Pyruvate metabolism
INOH
INOH website NAD+ + (S)-Malic acid = NADH + Pyruvic acid + CO2 - Glycolysis and Gluconeogenesis
INOH website NAD+ + (S)-Malic acid = NADH + Pyruvic acid + CO2 - Pyruvate metabolism
INOH website Pyruvate metabolism
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q99KE1 
TrEMBL Q3V2Y4
UniProt Splice Variant
Entrez Gene 107029 
UniGene Mm.407144 Mm.481432
RefSeq NM_145494 
OMIM
CCDS CCDS29339 
HPRD
IMGT
MGI ID MGI:2147351 
MGI Symbol Me2
EMBL AK042289 AK050933 AK050980 AK080403 AK156403 AK171157 BC004709
GenPept AAH04709  BAC31216  BAC34467  BAC34483  BAE33701  BAE42281  BAE43371 
ImmGen Me2 (murine) 
RNA Seq Atlas 107029