InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prkx

Summary

InnateDB Gene

IDBG-157778.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prkx

Gene Name

protein kinase, X-linked

Synonyms

Pkare; PKX1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035725

Encoded Proteins

IDBP-157780

protein kinase, X-linked

IDBP-252588

protein kinase, X-linked

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25028512

[Homo sapiens] MAP3K7 (TAK1) Ser412 phosphorylation is regulated by PRKACA and PRKX, and is essential for proper signalling, as well as proinflammatory cytokine induction by TLR/IL-1R activation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183943:
This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:77761411-77796278

Strand

Reverse strand

Band

Transcripts

ENSMUST00000036333	ENSMUSP00000045304
ENSMUST00000114044	ENSMUSP00000109678

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004691	cAMP-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0001935	endothelial cell proliferation
GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0018105	peptidyl-serine phosphorylation
GO:0030099	myeloid cell differentiation
GO:0030155	regulation of cell adhesion
GO:0030334	regulation of cell migration
GO:0031589	cell-substrate adhesion
GO:0043542	endothelial cell migration
GO:0046777	protein autophosphorylation
GO:0060562	epithelial tube morphogenesis
GO:0060993	kidney morphogenesis
GO:2000696	regulation of epithelial cell differentiation involved in kidney development