Version 5.4
Mus musculus Gene: Mapk4
Summary
InnateDB Gene IDBG-157792.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mapk4
Gene Name mitogen-activated protein kinase 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000024558
Encoded Proteins
IDBP-157794
mitogen-activated protein kinase 4
IDBP-532513
mitogen-activated protein kinase 4
IDBP-534363
mitogen-activated protein kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141639:
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets. [provided by RefSeq, Jul 2008]
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:73928486-74065359
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000091851 ENSMUSP00000089462
ENSMUST00000162863 ENSMUSP00000124408
ENSMUST00000159162 ENSMUSP00000123922
ENSMUST00000160601
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000165 MAPK cascade
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141639
View Gene Order
ENSBTAG00000009907
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_12
BCR pathway
NetPath_56
Prolactin pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q6P5G0
TrEMBL Q3TZE1
UniProt Splice Variant
Entrez Gene 225724
UniGene Mm.254517
RefSeq NM_172632 XM_006525900 XM_006525901
OMIM
CCDS CCDS37856
HPRD
IMGT
MGI ID MGI:2444559
MGI Symbol Mapk4
EMBL AK157930 BC058942 BC062911
GenPept AAH58942 AAH62911 BAE34268
RNA Seq Atlas 225724

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca