Version 5.4
Mus musculus Gene: Mlh3
Summary
InnateDB Gene IDBG-158237.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mlh3
Gene Name mutL homolog 3 (E coli)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000021245
Encoded Proteins
IDBP-158239
mutL homolog 3 (E coli)
IDBP-621247
mutL homolog 3 (E coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119684:
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:85234529-85270591
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000019378 ENSMUSP00000019378
ENSMUST00000166821 ENSMUSP00000129900
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0019237 centromeric DNA binding
GO:0030983 mismatched DNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006298 mismatch repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007130 synaptonemal complex assembly
GO:0007131 reciprocal meiotic recombination
GO:0007140 male meiosis
GO:0007144 female meiosis I
GO:0008104 protein localization
Cellular Component
GO:0000793 condensed chromosome
GO:0000795 synaptonemal complex
GO:0001673 male germ cell nucleus
GO:0005654 nucleoplasm
GO:0005712 chiasma
GO:0032300 mismatch repair complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000119684
View Gene Order
ENSBTAG00000019279
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03430
Mismatch repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_27271
Meiotic recombination pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
hsa03430
Mismatch repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.311981
RefSeq NM_175337 XM_006515707
OMIM
CCDS CCDS36497
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca