InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chd8

Summary

InnateDB Gene

IDBG-158392.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chd8

Gene Name

chromodomain helicase DNA binding protein 8

Synonyms

5830451P18Rik; AU015341; Duplin; HELSNF1; mKIAA1564

Species

Mus musculus

Ensembl Gene

ENSMUSG00000053754

Encoded Proteins

IDBP-158394

chromodomain helicase DNA binding protein 8

IDBP-536981

chromodomain helicase DNA binding protein 8

IDBP-532445

chromodomain helicase DNA binding protein 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100888:
This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:52198151-52237791

Strand

Reverse strand

Band

Transcripts

ENSMUST00000089752	ENSMUSP00000087184
ENSMUST00000149975	ENSMUSP00000122995
ENSMUST00000147827
ENSMUST00000147309
ENSMUST00000134329
ENSMUST00000136528
ENSMUST00000145404
ENSMUST00000140603	ENSMUSP00000118494
ENSMUST00000122823
ENSMUST00000155614
ENSMUST00000149694

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008013	beta-catenin binding
GO:0008094	DNA-dependent ATPase activity
GO:0016787	hydrolase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0035064	methylated histone binding
GO:0042393	histone binding
GO:0070016	armadillo repeat domain binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0030178	negative regulation of Wnt signaling pathway
GO:0032508	DNA duplex unwinding
GO:0043044	ATP-dependent chromatin remodeling
GO:0043066	negative regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045945	positive regulation of transcription from RNA polymerase III promoter
GO:0060070	canonical Wnt signaling pathway
GO:2000270	negative regulation of fibroblast apoptotic process