InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hcls1

Summary

InnateDB Gene

IDBG-158688.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hcls1

Gene Name

hematopoietic cell specific Lyn substrate 1

Synonyms

AW213261; HS1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022831

Encoded Proteins

IDBP-158690

hematopoietic cell specific Lyn substrate 1

IDBP-622196

hematopoietic cell specific Lyn substrate 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180353:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:36934983-36963212

Strand

Forward strand

Band

Transcripts

ENSMUST00000023531	ENSMUSP00000023531
ENSMUST00000164050	ENSMUSP00000127186
ENSMUST00000163755

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003779	actin binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0009725	response to hormone
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030041	actin filament polymerization
GO:0030218	erythrocyte differentiation
GO:0030833	regulation of actin filament polymerization
GO:0030854	positive regulation of granulocyte differentiation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0045651	positive regulation of macrophage differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897	positive regulation of protein kinase B signaling
GO:0071345	cellular response to cytokine stimulus
GO:2000107	negative regulation of leukocyte apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000180353

View Gene Order

ENSBTAG00000001009

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04530

Tight junction pathway

mmu05100

Bacterial invasion of epithelial cells pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_12

BCR pathway

NetPath_17

IL5 pathway

REACTOME

KEGG

hsa05130

Pathogenic Escherichia coli infection pathway

hsa04530

Tight junction pathway

hsa05100

Bacterial invasion of epithelial cells pathway

hsa05131

Shigellosis pathway

INOH

PID NCI

fcer1pathway

Fc-epsilon receptor I signaling in mast cells

Cross-References

SwissProt

P49710

TrEMBL

Q3V192 Q8CA06

UniProt Splice Variant

Entrez Gene

15163

UniGene

Mm.4091

RefSeq

NM_008225

OMIM

CCDS

CCDS37336

HPRD

IMGT

MGI ID

MGI:104568

MGI Symbol

Hcls1

EMBL

AK040049 AK132608 BC007469 D42120 X84797

GenPept

AAH07469 BAA07701 BAC30501 BAE21259 CAA59265

RNA Seq Atlas

15163