Version 5.4
Mus musculus Gene: Nat2
Summary
InnateDB Gene IDBG-158899.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nat2
Gene Name N-acetyltransferase 2 (arylamine N-acetyltransferase)
Synonyms AV377607
Species Mus musculus
Ensembl Gene ENSMUSG00000051147
Encoded Proteins
IDBP-158903
N-acetyltransferase 2 (arylamine N-acetyltransferase)
IDBP-619746
N-acetyltransferase 2 (arylamine N-acetyltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171428:
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:67494867-67502580
Strand Forward strand
Band B3.2
Transcripts
ENSMUST00000093470 ENSMUSP00000091181
ENSMUST00000163856 ENSMUSP00000130065
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004060 arylamine N-acetyltransferase activity
GO:0016407 acetyltransferase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171428
View Gene Order
ENSBTAG00000016473
Not yet available
Pathways
NETPATH
REACTOME
REACT_243247
Phase II conjugation pathway
REACT_188937
Metabolism pathway
REACT_237536
Acetylation pathway
REACT_232343
Biological oxidations pathway
KEGG
mmu00232
Caffeine metabolism pathway
mmu00983
Drug metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6732
Acetylation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_222472
Acetylation pathway
REACT_218176
Biological oxidations pathway
REACT_219139
Metabolism pathway
REACT_213008
Phase II conjugation pathway
KEGG
hsa00232
Caffeine metabolism pathway
hsa00983
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P50295
TrEMBL Q78ZC4
UniProt Splice Variant
Entrez Gene 17961
UniGene Mm.4695
RefSeq NM_001168577 NM_010874 XM_006509592
OMIM
CCDS CCDS22338
HPRD
IMGT
MGI ID MGI:109201
MGI Symbol Nat2
EMBL AJ250123 AJ251710 AJ314656 AJ314657 AJ314658 CH466569 U35886 U35887 U37249 U37250
GenPept AAA78943 AAA78944 AAA80353 AAA80354 CAC12845 CAC12846 CAC85415 CAC85416 CAC85417 EDL28705 EDL28706 EDL28707
RNA Seq Atlas 17961

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca