Version 5.4
Mus musculus Gene: Cd3g
Summary
InnateDB Gene IDBG-158962.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd3g
Gene Name CD3 antigen, gamma polypeptide
Synonyms Ctg-3; Ctg3; T3g
Species Mus musculus
Ensembl Gene ENSMUSG00000002033
Encoded Proteins
IDBP-158964
CD3 antigen, gamma polypeptide
IDBP-533743
CD3 antigen, gamma polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160654:
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:44969572-44980431
Strand Reverse strand
Band A5.2
Transcripts
ENSMUST00000002101 ENSMUSP00000002101
ENSMUST00000159019
ENSMUST00000160886 ENSMUSP00000125151
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007163 establishment or maintenance of cell polarity
GO:0007166 cell surface receptor signaling pathway
GO:0015031 protein transport
GO:0070228 regulation of lymphocyte apoptotic process
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042105 alpha-beta T cell receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160654
View Gene Order
ENSBTAG00000006453
Not yet available
Pathways
NETPATH
REACTOME
REACT_263643
PD-1 signaling pathway
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_210240
Role of phospholipids in phagocytosis pathway
REACT_216080
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_225145
Downstream TCR signaling pathway
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_230745
Immune System pathway
REACT_196487
FCGR activation pathway
REACT_215414
Translocation of ZAP-70 to Immunological synapse pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_229531
Adaptive Immune System pathway
REACT_225768
Generation of second messenger molecules pathway
REACT_222648
TCR signaling pathway
KEGG
mmu04640
Hematopoietic cell lineage pathway
mmu04660
T cell receptor signaling pathway pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_160274
FCGR activation pathway
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_12555
Downstream TCR signaling pathway
REACT_12623
Generation of second messenger molecules pathway
REACT_12596
Translocation of ZAP-70 to Immunological synapse pathway
REACT_12582
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_19324
PD-1 signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_12526
TCR signaling pathway
REACT_6802
Innate Immune System pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_213223
PD-1 signaling pathway
REACT_215545
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_212961
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_213843
Costimulation by the CD28 family pathway
REACT_205423
Downstream TCR signaling pathway
REACT_213138
Immune System pathway
REACT_215783
Role of phospholipids in phagocytosis pathway
REACT_211475
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_235805
FCGR activation pathway
REACT_214469
Adaptive Immune System pathway
REACT_216714
Innate Immune System pathway
REACT_218413
Generation of second messenger molecules pathway
REACT_202824
Translocation of ZAP-70 to Immunological synapse pathway
REACT_213465
TCR signaling pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
cxcr4_pathway
CXCR4-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
il12_2pathway
IL12-mediated signaling events
il12_stat4pathway
IL12 signaling mediated by STAT4
Cross-References
SwissProt P11942
TrEMBL E0CXP3 Q3U4Y3
UniProt Splice Variant
Entrez Gene 12502
UniGene Mm.335106
RefSeq NM_009850
OMIM
CCDS CCDS23123
HPRD
IMGT
MGI ID MGI:88333
MGI Symbol Cd3g
EMBL AC061963 AC166048 AK153980 AK153987 BC027528 CH466522 EF474453 GU456630 M18222 M18223 M18224 M18225 M18226 M18227 M58149 Y00635
GenPept AAA37400 AAA63289 AAH27528 ABS89006 ADD13993 BAE32293 BAE32297 CAA68667 EDL25627
RNA Seq Atlas 12502

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca