Version 5.4
Homo sapiens Gene: CALM1
Summary
InnateDB Gene IDBG-15903.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALM1
Gene Name calmodulin 1 (phosphorylase kinase, delta)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198668
Encoded Proteins
IDBP-15905
calmodulin 1 (phosphorylase kinase, delta)
IDBP-375792
calmodulin 1 (phosphorylase kinase, delta)
IDBP-596917
calmodulin 1 (phosphorylase kinase, delta)
IDBP-594775
calmodulin 1 (phosphorylase kinase, delta)
IDBP-597583
calmodulin 1 (phosphorylase kinase, delta)
IDBP-586259
calmodulin 1 (phosphorylase kinase, delta)
IDBP-594486
calmodulin 1 (phosphorylase kinase, delta)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 16893173
CALM1 (CaM) and NOS2 (iNOS) coordinately function to form a stable complex that is part of a rapid host response that functions within the first 30 min following bacterial infection to upregulate the innate immune system involving macrophage activation.
InnateDB Annotation from Orthologs
Summary
PMID 16893173
[Mus musculus] Calm1 (CaM) and Nos2 (iNOS) coordinately function to form a stable complex that is part of a rapid host response that functions within the first 30 min following bacterial infection to upregulate the innate immune system involving macrophage activation.
Entrez Gene
Summary This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:90396502-90408261
Strand Forward strand
Band q32.11
Transcripts
ENST00000356978 ENSP00000349467
ENST00000447653 ENSP00000403491
ENST00000557020 ENSP00000451062
ENST00000555132
ENST00000557123
ENST00000556757
ENST00000553995
ENST00000553630 ENSP00000451646
ENST00000553542 ENSP00000450829
ENST00000553964
ENST00000544280 ENSP00000442853
ENST00000555267
ENST00000553422 ENSP00000450425
ENST00000554296
ENST00000556721
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 414 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 414 [view]
Protein-Protein 412 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0019904 protein domain specific binding
GO:0031432 titin binding
GO:0031996 thioesterase binding
GO:0031997 N-terminal myristoylation domain binding
GO:0043274 phospholipase binding
GO:0044325 ion channel binding
GO:0072542 protein phosphatase activator activity
Biological Process
GO:0002027 regulation of heart rate
GO:0002576 platelet degranulation
GO:0005513 detection of calcium ion
GO:0005975 carbohydrate metabolic process
GO:0005980 glycogen catabolic process
GO:0006006 glucose metabolic process
GO:0006936 muscle contraction
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0007603 phototransduction, visible light
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016056 rhodopsin mediated signaling pathway
GO:0016310 phosphorylation
GO:0021762 substantia nigra development
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0030168 platelet activation
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0032465 regulation of cytokinesis
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0035307 positive regulation of protein dephosphorylation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0046209 nitric oxide metabolic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051592 response to calcium ion
GO:0055117 regulation of cardiac muscle contraction
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0061024 membrane organization
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
Cellular Component
GO:0000922 spindle pole
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0005886 plasma membrane
GO:0030017 sarcomere
GO:0034704 calcium channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000001175
View Gene Order
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
NetPath_24
TSLP pathway
REACTOME
REACT_15408
Cam-PDE 1 activation pathway
REACT_15502
CaMK IV-mediated phosphorylation of CREB pathway
REACT_9000
Calmodulin induced events pathway
REACT_9053
CaM pathway pathway
REACT_111064
DAG and IP3 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_9417
Signaling by EGFR pathway
REACT_15426
PLC beta mediated events pathway
REACT_15334
DARPP-32 events pathway
REACT_15295
Opioid Signalling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_20652
Activation of CaMK IV pathway
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_1008
Glycogen breakdown (glycogenolysis) pathway
REACT_111176
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_12477
eNOS activation pathway
REACT_20546
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_20661
CREB phosphorylation through the activation of CaMKK pathway
REACT_20642
CREB phosphorylation through the activation of CaMKII pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_20558
Smooth Muscle Contraction pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_172761
Ca2+ pathway pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_12389
eNOS activation and regulation pathway
REACT_11045
Signaling by Wnt pathway
REACT_13685
Neuronal System pathway
REACT_12529
Signaling by VEGF pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_21322
Ionotropic activity of Kainate Receptors pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_15526
G-protein mediated events pathway
REACT_21312
Activation of Kainate Receptors upon glutamate binding pathway
REACT_75774
Adaptive Immune System pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_6900
Immune System pathway
REACT_228024
VEGFR2 mediated cell proliferation pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_160125
Visual phototransduction pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_21346
Activation of Ca-permeable Kainate Receptor pathway
REACT_17044
Muscle contraction pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_163722
The phototransduction cascade pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111217
Metabolism pathway
REACT_163919
Inactivation, recovery and regulation of the phototransduction cascade pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_15307
Ca-dependent events pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
REACT_604
Hemostasis pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04740
Olfactory transduction pathway
hsa04720
Long-term potentiation pathway
hsa05010
Alzheimer's disease pathway
hsa05214
Glioma pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04910
Insulin signaling pathway pathway
hsa04020
Calcium signaling pathway pathway
hsa04916
Melanogenesis pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04114
Oocyte meiosis pathway
hsa04971
Gastric acid secretion pathway
hsa04970
Salivary secretion pathway
hsa04744
Phototransduction pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
anthraxpathway
Cellular roles of Anthrax toxin
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
erbb1_downstream_pathway
ErbB1 downstream signaling
bcr_5pathway
BCR signaling pathway
ras_pathway
Regulation of Ras family activation
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
smad2_3pathway
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
vegfr1_pathway
VEGFR1 specific signals
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
il2_pi3kpathway
IL2 signaling events mediated by PI3K
insulin_glucose_pathway
Insulin-mediated glucose transport
ncadherinpathway
N-cadherin signaling events
ifngpathway
IFN-gamma pathway
p38_mkk3_6pathway
p38 MAPK signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.282410
RefSeq NM_006888 XM_006720258
HUGO
OMIM
CCDS CCDS9892
HPRD 00241
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca