Version 5.4
Mus musculus Gene: Mapk13
Summary
InnateDB Gene IDBG-159128.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mapk13
Gene Name mitogen-activated protein kinase 13
Synonyms SAPK4; Serk4
Species Mus musculus
Ensembl Gene ENSMUSG00000004864
Encoded Proteins
IDBP-159130
mitogen-activated protein kinase 13
IDBP-537057
mitogen-activated protein kinase 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156711:
This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:28769307-28778698
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000004986 ENSMUSP00000004986
ENSMUST00000124099
ENSMUST00000129096 ENSMUSP00000115659
ENSMUST00000133786
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 83 [view]
Protein-Protein 83 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000165 MAPK cascade
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0006970 response to osmotic stress
GO:0007049 cell cycle
GO:0018105 peptidyl-serine phosphorylation
GO:0032755 positive regulation of interleukin-6 production
GO:0035556 intracellular signal transduction
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000156711
View Gene Order
ENSBTAG00000010007
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_227951
Signaling by VEGF pathway
REACT_230745
Immune System pathway
REACT_243212
DSCAM interactions pathway
REACT_239722
Signalling to RAS pathway
REACT_207601
p38MAPK events pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_231290
Signalling to ERKs pathway
REACT_211125
NOD1/2 Signaling Pathway pathway
REACT_248921
Signalling by NGF pathway
REACT_206758
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_188257
Signal Transduction pathway
REACT_211261
Mitochondrial biogenesis pathway
REACT_223082
Cell-Cell communication pathway
REACT_205688
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
KEGG
mmu04370
VEGF signaling pathway pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04912
GnRH signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04622
RIG-I-like receptor signaling pathway pathway
mmu04621
NOD-like receptor signaling pathway pathway
mmu05140
Leishmaniasis pathway
mmu04380
Osteoclast differentiation pathway
mmu05145
Toxoplasmosis pathway
mmu05160
Hepatitis C pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
BMP2 signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75776
NOD1/2 Signaling Pathway pathway
REACT_12065
p38MAPK events pathway
REACT_12033
Signalling to RAS pathway
REACT_25299
DSCAM interactions pathway
REACT_11061
Signalling by NGF pathway
REACT_111155
Cell-Cell communication pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_111102
Signal Transduction pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04010
MAPK signaling pathway pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa05140
Leishmaniasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05131
Shigellosis pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
p38gammadeltapathway
Signaling mediated by p38-gamma and p38-delta
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.27970
RefSeq NM_011950
OMIM
CCDS CCDS28584
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca