InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sstr3

Summary

InnateDB Gene

IDBG-159482.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sstr3

Gene Name

somatostatin receptor 3

Synonyms

Smstr-3; Smstr3; sst3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000044933

Encoded Proteins

IDBP-159484

somatostatin receptor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:78537015-78544345

Strand

Reverse strand

Band

Transcripts

ENSMUST00000053239

ENSMUSP00000058040

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004994	somatostatin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007283	spermatogenesis
GO:0021549	cerebellum development
GO:0030900	forebrain development
GO:0038170	somatostatin signaling pathway
GO:0042594	response to starvation
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0016021	integral component of membrane
GO:0031513	nonmotile primary cilium
GO:0060170	ciliary membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

null

View Gene Order

ENSBTAG00000008910

Not yet available

Pathways

NETPATH

REACTOME

REACT_223625

GPCR downstream signaling pathway

REACT_254215

Signaling by GPCR pathway

REACT_261161

Class A/1 (Rhodopsin-like receptors) pathway

REACT_231468

GPCR ligand binding pathway

REACT_235286

Peptide ligand-binding receptors pathway

REACT_250376

G alpha (i) signalling events pathway

REACT_188257

Signal Transduction pathway

KEGG

mmu04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P30935

TrEMBL

UniProt Splice Variant

Entrez Gene

20607

UniGene

Mm.211411

RefSeq

NM_009218 XM_006520669 XM_006520670

OMIM

CCDS

CCDS27617

HPRD

IMGT

MGI ID

MGI:98329

MGI Symbol

Sstr3

EMBL

AK136904 AL590144 BC120843 BC137670 M91000

GenPept

AAA40144 AAI20844 AAI37671 BAE23164

RNA Seq Atlas

20607