Mus musculus Gene: Rac2 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-159514.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | Rac2 | ||||||||||||||||||||||||||||
Gene Name | RAS-related C3 botulinum substrate 2 | ||||||||||||||||||||||||||||
Synonyms | AI323801; AI452260 | ||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000033220 | ||||||||||||||||||||||||||||
Encoded Proteins |
RAS-related C3 botulinum substrate 2
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||
Summary |
Rac2 is modified by Escherichia coli protein CNF1 , which then interacts with the innate immune adaptors Ripk1 and Ripk2 to trigger an anti-bacterial immune response. This response was protective and increased the ability of the host to restrict pathogen growth, thus defining a mechanism of effector-triggered immunity that contributes to how metazoans defend against microbes with pathogenic potential. (Demonstrated in human)
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||
Summary |
[Homo sapiens] RAC2 is modified by Escherichia coli protein CNF1, which then interacts with the innate immune adaptors RIPK1 and RIPK2 to trigger an anti-bacterial immune response. This response was protective and increased the ability of the host to restrict pathogen growth, thus defining a mechanism of effector-triggered immunity that contributes to how metazoans defend against microbes with pathogenic potential.
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Entrez Gene | |||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128340:
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. [provided by RefSeq, Jul 2008] This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 15:78559169-78572783 | ||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||
Band | E1 | ||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME |
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Signaling by Rho GTPases pathway
Sema4D induced cell migration and growth-cone collapse pathway
GPVI-mediated activation cascade pathway
G alpha (12/13) signalling events pathway
Axon guidance pathway
Rho GTPase cycle pathway
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Semaphorin interactions pathway
Signal Transduction pathway
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KEGG |
Axon guidance pathway
VEGF signaling pathway pathway
Wnt signaling pathway pathway
Colorectal cancer pathway
Fc epsilon RI signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Regulation of actin cytoskeleton pathway
MAPK signaling pathway pathway
Adherens junction pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
B cell receptor signaling pathway pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Viral myocarditis pathway
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INOH |
CD4 T cell receptor signaling pathway
HGF signaling pathway pathway
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PID NCI | |||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME |
GPVI-mediated activation cascade pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Sema4D induced cell migration and growth-cone collapse pathway
Sema4D in semaphorin signaling pathway
PCP/CE pathway pathway
Developmental Biology pathway
beta-catenin independent WNT signaling pathway
Semaphorin interactions pathway
Signaling by Wnt pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Hemostasis pathway
Sema4D in semaphorin signaling pathway
Signaling by GPCR pathway
Sema4D induced cell migration and growth-cone collapse pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Rho GTPase cycle pathway
Signal Transduction pathway
GPVI-mediated activation cascade pathway
Signaling by Rho GTPases pathway
Axon guidance pathway
GPCR downstream signaling pathway
G alpha (12/13) signalling events pathway
Semaphorin interactions pathway
Developmental Biology pathway
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KEGG |
Regulation of actin cytoskeleton pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Colorectal cancer pathway
Wnt signaling pathway pathway
MAPK signaling pathway pathway
Axon guidance pathway
Adherens junction pathway
Leukocyte transendothelial migration pathway
B cell receptor signaling pathway pathway
Focal adhesion pathway
Natural killer cell mediated cytotoxicity pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Viral myocarditis pathway
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INOH |
CD4 T cell receptor signaling pathway
HGF signaling pathway pathway
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PID NCI |
IL8- and CXCR2-mediated signaling events
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Cross-References | |||||||||||||||||||||||||||||
SwissProt | Q05144 | ||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | 19354 | ||||||||||||||||||||||||||||
UniGene | Mm.1972 | ||||||||||||||||||||||||||||
RefSeq | NM_009008 | ||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | CCDS27619 | ||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
MGI ID | MGI:97846 | ||||||||||||||||||||||||||||
MGI Symbol | Rac2 | ||||||||||||||||||||||||||||
EMBL | AK007561 AK144136 AK171321 BC005455 X53247 | ||||||||||||||||||||||||||||
GenPept | AAH05455 BAB25109 BAE25721 BAE42390 CAA37337 | ||||||||||||||||||||||||||||
RNA Seq Atlas | 19354 | ||||||||||||||||||||||||||||