Version 5.4
Mus musculus Gene: Htra2
Summary
InnateDB Gene IDBG-159586.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Htra2
Gene Name HtrA serine peptidase 2
Synonyms AI481710; mnd2; Omi; Prss25
Species Mus musculus
Ensembl Gene ENSMUSG00000068329
Encoded Proteins
IDBP-159588
HtrA serine peptidase 2
IDBP-252769
HtrA serine peptidase 2
IDBP-252771
HtrA serine peptidase 2
IDBP-789394
HtrA serine peptidase 2
IDBP-789395
HtrA serine peptidase 2
IDBP-542082
HtrA serine peptidase 2
IDBP-540574
HtrA serine peptidase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115317:
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:83051266-83055273
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000089645 ENSMUSP00000087073
ENSMUST00000113963 ENSMUSP00000109596
ENSMUST00000113962 ENSMUSP00000109595
ENSMUST00000122955 ENSMUSP00000138153
ENSMUST00000154829
ENSMUST00000132099 ENSMUSP00000138148
ENSMUST00000134606 ENSMUSP00000115547
ENSMUST00000144058
ENSMUST00000150217 ENSMUSP00000118234
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006672 ceramide metabolic process
GO:0007005 mitochondrion organization
GO:0007628 adult walking behavior
GO:0008344 adult locomotory behavior
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009635 response to herbicide
GO:0010942 positive regulation of cell death
GO:0019742 pentacyclic triterpenoid metabolic process
GO:0030900 forebrain development
GO:0034605 cellular response to heat
GO:0040014 regulation of multicellular organism growth
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048666 neuron development
GO:0060548 negative regulation of cell death
GO:0071363 cellular response to growth factor stimulus
GO:0097193 intrinsic apoptotic signaling pathway
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0035631 CD40 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115317
View Gene Order
ENSBTAG00000020124
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05012
Parkinson's disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05012
Parkinson's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3YX28
UniProt Splice Variant
Entrez Gene 64704
UniGene Mm.21880
RefSeq NM_019752
OMIM
CCDS CCDS20267
HPRD
IMGT
MGI ID MGI:1928676
MGI Symbol Htra2
EMBL AC104324
GenPept
RNA Seq Atlas 64704

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca