Version 5.4
Mus musculus Gene: Iqgap3
Summary
InnateDB Gene IDBG-159778.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Iqgap3
Gene Name IQ motif containing GTPase activating protein 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000028068
Encoded Proteins
IDBP-159780
IQ motif containing GTPase activating protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183856:
Gene Information
Type Protein coding
Genomic Location Chromosome 3:88082051-88121048
Strand Forward strand
Band F1
Transcripts
ENSMUST00000071812 ENSMUSP00000071715
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005099 Ras GTPase activator activity
GO:0005515 protein binding
GO:0017016 Ras GTPase binding
GO:0017048 Rho GTPase binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000187 activation of MAPK activity
GO:0001934 positive regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0008361 regulation of cell size
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0032320 positive regulation of Ras GTPase activity
GO:0033601 positive regulation of mammary gland epithelial cell proliferation
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0070371 ERK1 and ERK2 cascade
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0016328 lateral plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000183856
View Gene Order
ENSBTAG00000006882
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
Cross-References
SwissProt
TrEMBL F8VQ29 Q3UQP1
UniProt Splice Variant
Entrez Gene 404710
UniGene Mm.331133 Mm.418602
RefSeq NM_001033484 XM_006501643 XM_006501644
OMIM
CCDS CCDS38478
HPRD
IMGT
MGI ID MGI:3028642
MGI Symbol Iqgap3
EMBL AC137525 AK142260
GenPept BAE24998
RNA Seq Atlas 404710

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca