Mus musculus Gene: Gsk3b
Summary
InnateDB Gene IDBG-159859.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gsk3b
Gene Name glycogen synthase kinase 3 beta
Synonyms 7330414F15Rik; 8430431H08Rik; C86142; GSK-3; GSK-3beta; GSK3;
Species Mus musculus
Ensembl Gene ENSMUSG00000022812
Encoded Proteins
glycogen synthase kinase 3 beta
glycogen synthase kinase 3 beta
Protein Structure
InnateDB Annotation
Summary
Gsk3b is a regulator of LPS-mediated septic shock. Gsk3b deficiency results in the attenuation of endotoxemia.
Gsk3b functions downstream of Tlr2-stimulation to induce the expression of the monocyte chemoattractant protein 1, Ccl2.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] GSK3B is a cytoplasmic serine/threonine protein kinase that regulates NF-kappaB activation and the proliferation and survival of pancreatic cancer cells.
[Homo sapiens] GSK3B inhibits MEKK4 activity and prevents its activation of JNK and p38, thus controlling MEKK4 dimerization both positively and negatively by regulating its interaction with specific proteins.
[Homo sapiens] GSK3B activation is accelerated by TLR4 which leads to deterioration of serum-deprivation-induced apoptosis and beta-arrestin 2 represents an inhibitory effect on the TLR4-mediated apoptotic cascade, through controlling the homeostasis of activation and inactivation of GSK3B.
[Homo sapiens] GSK3B is a regulator of LPS-mediated septic shock. GSK3B deficiency results in the attenuation of endotoxemia. (Demonstrated in murine model)
[Homo sapiens] GSK3B functions downstream of TLR2-stimulation to induce the expression of the monocyte chemoattractant protein 1, CCL2. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000082701:
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:38089001-38246084
Strand Forward strand
Band B3
Transcripts
ENSMUST00000023507 ENSMUSP00000023507
ENSMUST00000114750 ENSMUSP00000110398
ENSMUST00000134870
ENSMUST00000132057
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 244 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 57 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 244 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008013 beta-catenin binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0034236 protein kinase A catalytic subunit binding
GO:0035255 ionotropic glutamate receptor binding
GO:0048156 tau protein binding
GO:0050321 tau-protein kinase activity
GO:0051059 NF-kappaB binding
Biological Process
GO:0000320 re-entry into mitotic cell cycle
GO:0001837 epithelial to mesenchymal transition
GO:0001954 positive regulation of cell-matrix adhesion
GO:0005977 glycogen metabolic process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006468 protein phosphorylation
GO:0006611 protein export from nucleus
GO:0006983 ER overload response
GO:0007010 cytoskeleton organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007409 axonogenesis
GO:0007520 myoblast fusion
GO:0007623 circadian rhythm
GO:0008283 cell proliferation
GO:0009887 organ morphogenesis
GO:0010226 response to lithium ion
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010977 negative regulation of neuron projection development
GO:0014043 negative regulation of neuron maturation
GO:0014902 myotube differentiation
GO:0016055 Wnt signaling pathway
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0021766 hippocampus development
GO:0030010 establishment of cell polarity
GO:0031333 negative regulation of protein complex assembly
GO:0031334 positive regulation of protein complex assembly
GO:0032091 negative regulation of protein binding
GO:0032092 positive regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032855 positive regulation of Rac GTPase activity
GO:0032886 regulation of microtubule-based process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035372 protein localization to microtubule
GO:0035556 intracellular signal transduction
GO:0036016 cellular response to interleukin-3
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043407 negative regulation of MAP kinase activity
GO:0044027 hypermethylation of CpG island
GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045444 fat cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046827 positive regulation of protein export from nucleus
GO:0048168 regulation of neuronal synaptic plasticity
GO:0050774 negative regulation of dendrite morphogenesis
GO:0051534 negative regulation of NFAT protein import into nucleus
GO:0060070 canonical Wnt signaling pathway
GO:0071109 superior temporal gyrus development
GO:0071260 cellular response to mechanical stimulus
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000738 positive regulation of stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030426 growth cone
GO:0030529 ribonucleoprotein complex
GO:0030877 beta-catenin destruction complex
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043227 membrane-bounded organelle
GO:0043234 protein complex
GO:0044297 cell body
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Cell Cycle, Mitotic pathway
PI3K/AKT activation pathway
Disease pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
Signaling by Wnt pathway
Hedgehog 'off' state pathway
Beta-catenin phosphorylation cascade pathway
Signaling by WNT in cancer pathway
Cellular responses to stress pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Degradation of beta-catenin by the destruction complex pathway
AMER1 mutants destabilize the destruction complex pathway
PIP3 activates AKT signaling pathway
Cell Cycle pathway
Immune System pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
APC truncation mutants have impaired AXIN binding pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Degradation of GLI2 by the proteasome pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
Signaling by EGFR pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Cellular response to heat stress pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
AXIN missense mutants destabilize the destruction complex pathway
TCF dependent signaling in response to WNT pathway
GLI3 is processed to GLI3R by the proteasome pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
PI3K/AKT Signaling in Cancer pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
TCF7L2 mutants don't bind CTBP pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
Developmental Biology pathway
truncations of AMER1 destabilize the destruction complex pathway
GAB1 signalosome pathway
Ubiquitin-dependent degradation of Cyclin D pathway
Signaling by Hedgehog pathway
AKT phosphorylates targets in the cytosol pathway
Semaphorin interactions pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Regulation of HSF1-mediated heat shock response pathway
truncated APC mutants destabilize the destruction complex pathway
Signaling by FGFR pathway
CRMPs in Sema3A signaling pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
Signaling by EGFR in Cancer pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
S Phase pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Cell cycle pathway
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Axon guidance pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Melanogenesis pathway
Alzheimer's disease pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Endometrial cancer pathway
Prostate cancer pathway
Basal cell carcinoma pathway
INOH
Hedgehog signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Wnt signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
Notch pathway
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
Wnt pathway
TCR pathway
BCR pathway
IL1 pathway
IL3 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
Leptin pathway
TWEAK pathway
Prolactin pathway
REACTOME
Signaling by FGFR in disease pathway
truncated APC mutants destabilize the destruction complex pathway
Cellular responses to stress pathway
Developmental Biology pathway
Beta-catenin phosphorylation cascade pathway
Signalling by NGF pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
AMER1 mutants destabilize the destruction complex pathway
Downstream signaling of activated FGFR pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Regulation of HSF1-mediated heat shock response pathway
Semaphorin interactions pathway
AXIN missense mutants destabilize the destruction complex pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by Wnt pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI2 by the proteasome pathway
GLI3 is processed to GLI3R by the proteasome pathway
Signaling by SCF-KIT pathway
Axon guidance pathway
CRMPs in Sema3A signaling pathway
Degradation of beta-catenin by the destruction complex pathway
Fc epsilon receptor (FCERI) signaling pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
AKT phosphorylates targets in the cytosol pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
NGF signalling via TRKA from the plasma membrane pathway
Cellular response to heat stress pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Cell cycle pathway
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Axon guidance pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Melanogenesis pathway
Alzheimer's disease pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Endometrial cancer pathway
Prostate cancer pathway
Basal cell carcinoma pathway
INOH
Hedgehog signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Wnt signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
Cell cycle: g1/s check point [Biocarta view]
Segmentation clock [Biocarta view]
Deregulation of cdk5 in alzheimers disease [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Regulation of eif2 [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
Skeletal muscle hypertrophy is regulated via akt-mtor pathway [Biocarta view]
Phosphoinositides and their downstream targets [Biocarta view]
Wnt signaling pathway [Biocarta view]
PID NCI
Trk receptor signaling mediated by PI3K and PLC-gamma
LPA receptor mediated events
BMP receptor signaling
Aurora A signaling
Reelin signaling pathway
Presenilin action in Notch and Wnt signaling
LKB1 signaling events
p53 pathway
Integrin-linked kinase signaling
Glucocorticoid receptor regulatory network
Signaling events mediated by Stem cell factor receptor (c-Kit)
C-MYC pathway
CDC42 signaling events
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Hedgehog signaling events mediated by Gli proteins
Regulation of Androgen receptor activity
Validated transcriptional targets of deltaNp63 isoforms
Insulin-mediated glucose transport
Cross-References
SwissProt Q9WV60
TrEMBL E9QAQ5 Q3TB31 Q5KU03
UniProt Splice Variant
Entrez Gene 56637
UniGene Mm.394930 Mm.405569 Mm.407857 Mm.418347 Mm.475266
RefSeq NM_019827
OMIM
CCDS CCDS28163
HPRD
IMGT
MGI ID MGI:1861437
MGI Symbol Gsk3b
EMBL AB066114 AC120020 AC154284 AF156099 AK154293 AK170965 AK171482 BC006936 BC060743 CH466521
GenPept AAD39258 AAH06936 AAH60743 BAD86827 BAE32494 BAE42146 BAE42483 EDK97969
ImmGen Gsk3b (murine)
RNA Seq Atlas 56637