Version 5.4
Mus musculus Gene: Egr2
Summary
InnateDB Gene IDBG-159898.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Egr2
Gene Name early growth response 2
Synonyms Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25; Zfp-6
Species Mus musculus
Ensembl Gene ENSMUSG00000037868
Encoded Proteins
IDBP-159900
early growth response 2
IDBP-270880
early growth response 2
IDBP-532204
early growth response 2
IDBP-539167
early growth response 2
IDBP-536619
early growth response 2
IDBP-534765
early growth response 2
IDBP-538637
early growth response 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122877:
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:67535475-67542188
Strand Forward strand
Band B5.1
Transcripts
ENSMUST00000048289 ENSMUSP00000041053
ENSMUST00000105438 ENSMUSP00000101078
ENSMUST00000145754 ENSMUSP00000116621
ENSMUST00000145936 ENSMUSP00000115709
ENSMUST00000130933 ENSMUSP00000116502
ENSMUST00000146986 ENSMUSP00000118941
ENSMUST00000127820 ENSMUSP00000116799
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 64 [view]
Protein-Protein 10 [view]
Protein-DNA 53 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
GO:0071837 HMG box domain binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006611 protein export from nucleus
GO:0007611 learning or memory
GO:0007622 rhythmic behavior
GO:0008045 motor neuron axon guidance
GO:0014037 Schwann cell differentiation
GO:0016925 protein sumoylation
GO:0021569 rhombomere 3 development
GO:0021612 facial nerve structural organization
GO:0021660 rhombomere 3 formation
GO:0021666 rhombomere 5 formation
GO:0030278 regulation of ossification
GO:0032868 response to insulin
GO:0035284 brain segmentation
GO:0035914 skeletal muscle cell differentiation
GO:0042552 myelination
GO:0043066 negative regulation of apoptotic process
GO:0045444 fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048168 regulation of neuronal synaptic plasticity
GO:0071310 cellular response to organic substance
GO:0071320 cellular response to cAMP
GO:0071371 cellular response to gonadotropin stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000122877
View Gene Order
ENSBTAG00000046409
Not yet available
Pathways
NETPATH
REACTOME
REACT_27166
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_200794
Mus musculus biological processes pathway
REACT_188576
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
KEGG
INOH
PID NCI
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
il4_2pathway
IL4-mediated signaling events
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.290421
RefSeq NM_010118 XM_006513209 XM_006513210 XM_006513211 XM_006513212 XM_006513213
OMIM
CCDS CCDS35927
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca