InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp5a1

Summary

InnateDB Gene

IDBG-160170.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp5a1

Gene Name

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1

Synonyms

AI035633; AL022851; AL023067; Atpm; D18Ertd206e; Mom2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025428

Encoded Proteins

IDBP-160172

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1

IDBP-251086

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1

IDBP-533975

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152234:
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:77773729-77782869

Strand

Forward strand

Band

Transcripts

ENSMUST00000026495	ENSMUSP00000026495
ENSMUST00000114748	ENSMUSP00000110396
ENSMUST00000135678	ENSMUSP00000120436
ENSMUST00000128073
ENSMUST00000146869

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887	ATPase activity
GO:0042288	MHC class I protein binding
GO:0044822	poly(A) RNA binding
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0006200	ATP catabolic process
GO:0006629	lipid metabolic process
GO:0015986	ATP synthesis coupled proton transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0046034	ATP metabolic process
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0005886	plasma membrane
GO:0008180	COP9 signalosome
GO:0016020	membrane
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)
GO:0070062	extracellular vesicular exosome