Version 5.4
Mus musculus Gene: Wdr1
Summary
InnateDB Gene IDBG-160219.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdr1
Gene Name WD repeat domain 1
Synonyms Aip1; D5Wsu185e; rede
Species Mus musculus
Ensembl Gene ENSMUSG00000005103
Encoded Proteins
IDBP-160221
WD repeat domain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071127:
This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:38526814-38561666
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000005234 ENSMUSP00000005234
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007605 sensory perception of sound
GO:0048713 regulation of oligodendrocyte differentiation
Cellular Component
GO:0002102 podosome
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0015629 actin cytoskeleton
GO:0030054 cell junction
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000071127
View Gene Order
ENSBTAG00000013607
Not yet available
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_224553
Hemostasis pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O88342
TrEMBL Q3TE06 Q3TJY2
UniProt Splice Variant
Entrez Gene 22388
UniGene Mm.393965
RefSeq NM_011715
OMIM
CCDS CCDS51485
HPRD
IMGT
MGI ID MGI:1337100
MGI Symbol Wdr1
EMBL AF020055 AK153338 AK167241 AK167275 AK169835 AK169893 BC119358 BC125295 CH466524
GenPept AAD05043 AAI19359 AAI25296 BAE31916 BAE39363 BAE39387 BAE41400 BAE41442 EDL37559
RNA Seq Atlas 22388

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca