Version 5.4
Homo sapiens Gene: TRMT2A
Summary
InnateDB Gene IDBG-1603.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRMT2A
Gene Name tRNA methyltransferase 2 homolog A (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000099899
Encoded Proteins
IDBP-1605
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
IDBP-292552
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
IDBP-292556
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
IDBP-362741
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
IDBP-362744
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
IDBP-362754
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
IDBP-362757
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:20111866-20117392
Strand Reverse strand
Band q11.21
Transcripts
ENST00000252136 ENSP00000252136
ENST00000404751 ENSP00000384968
ENST00000403707 ENSP00000385807
ENST00000439169 ENSP00000395738
ENST00000444845 ENSP00000397744
ENST00000444256 ENSP00000392261
ENST00000445045 ENSP00000393911
ENST00000480339
ENST00000487668
ENST00000487378
ENST00000494820
ENST00000492988
ENST00000471040
ENST00000488335
ENST00000463710
ENST00000459644
ENST00000468917
ENST00000480460
ENST00000494641
ENST00000464535
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0008176 tRNA (guanine-N7-)-methyltransferase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001510 RNA methylation
GO:0006396 RNA processing
GO:0006400 tRNA modification
GO:0006464 cellular protein modification process
GO:0008152 metabolic process
GO:0031167 rRNA methylation
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022721
View Gene Order
ENSBTAG00000019871
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.713579
RefSeq NM_001257994 NM_022727 NM_182984
HUGO
OMIM
CCDS CCDS13774 CCDS58793
HPRD 13719
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca