Version 5.4
Mus musculus Gene: Numbl
Summary
InnateDB Gene IDBG-160322.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Numbl
Gene Name numb-like
Synonyms nbl
Species Mus musculus
Ensembl Gene ENSMUSG00000063160
Encoded Proteins
IDBP-160324
numb-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18299187
[Homo sapiens] NUMBL interacts with TAB2 (MAP3K7IP2) and inhibits TNF alpha and IL-1Beta-induced NF-kappaB activation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105245:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27258433-27282144
Strand Forward strand
Band A3
Transcripts
ENSMUST00000079258 ENSMUSP00000078245
ENSMUST00000144010
ENSMUST00000132897
ENSMUST00000149805
ENSMUST00000134215
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007399 nervous system development
GO:0007405 neuroblast proliferation
GO:0007409 axonogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0019538 protein metabolic process
GO:0021670 lateral ventricle development
GO:0021849 neuroblast division in subventricular zone
GO:0030900 forebrain development
GO:0034332 adherens junction organization
GO:0050769 positive regulation of neurogenesis
GO:0050775 positive regulation of dendrite morphogenesis
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105245
View Gene Order
ENSBTAG00000019461
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04330
Notch signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
REACTOME
KEGG
hsa04330
Notch signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt O08919
TrEMBL Q3UH86
UniProt Splice Variant
Entrez Gene 18223
UniGene Mm.458153
RefSeq NM_010950 XM_006539615 XM_006539616 XM_006539617
OMIM
CCDS CCDS21016
HPRD
IMGT
MGI ID MGI:894702
MGI Symbol Numbl
EMBL AK147523 BC068116 BC098097 CH466593 U96441
GenPept AAB58697 AAH68116 AAH98097 BAE27971 EDL24192
RNA Seq Atlas 18223

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca