Version 5.4
Mus musculus Gene: Ltbp4
Summary
InnateDB Gene IDBG-160426.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ltbp4
Gene Name latent transforming growth factor beta binding protein 4
Synonyms 2310046A13Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000040488
Encoded Proteins
IDBP-160428
latent transforming growth factor beta binding protein 4
IDBP-264675
latent transforming growth factor beta binding protein 4
IDBP-401228
latent transforming growth factor beta binding protein 4
IDBP-401227
latent transforming growth factor beta binding protein 4
IDBP-401226
latent transforming growth factor beta binding protein 4
IDBP-535635
latent transforming growth factor beta binding protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090006:
The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27305136-27337692
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000038618 ENSMUSP00000037536
ENSMUST00000108369 ENSMUSP00000104006
ENSMUST00000121175 ENSMUSP00000113674
ENSMUST00000118583 ENSMUSP00000113523
ENSMUST00000118961 ENSMUSP00000113746
ENSMUST00000134464
ENSMUST00000125455 ENSMUSP00000120326
ENSMUST00000148594
ENSMUST00000129471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0030162 regulation of proteolysis
GO:0046879 hormone secretion
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000090006
View Gene Order
ENSBTAG00000004757
Not yet available
Pathways
NETPATH
REACTOME
REACT_198996
Elastic fibre formation pathway
REACT_198998
Molecules associated with elastic fibres pathway
REACT_206066
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.272251
RefSeq NM_001113549 NM_175641 XM_006539458
OMIM
CCDS CCDS21017 CCDS52158
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca