InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbxw11

Summary

InnateDB Gene

IDBG-160575.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxw11

Gene Name

F-box and WD-40 domain protein 11

Synonyms

2310065A07Rik; AA536858; BTRC2; BTRCP2; Fbxw1b; HOS

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020271

Encoded Proteins

IDBP-160579

F-box and WD-40 domain protein 11

IDBP-160581

F-box and WD-40 domain protein 11

IDBP-262534

F-box and WD-40 domain protein 11

IDBP-536404

F-box and WD-40 domain protein 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072803:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:32642724-32746816

Strand

Forward strand

Band

Transcripts

ENSMUST00000076383	ENSMUSP00000075721
ENSMUST00000093205	ENSMUSP00000090893
ENSMUST00000109366	ENSMUSP00000104991
ENSMUST00000137898
ENSMUST00000143290	ENSMUSP00000116834

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0006470	protein dephosphorylation
GO:0007049	cell cycle
GO:0016055	Wnt signaling pathway
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648	protein destabilization
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0042752	regulation of circadian rhythm
GO:0042753	positive regulation of circadian rhythm
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045862	positive regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048511	rhythmic process