Version 5.4
Mus musculus Gene: Sh3gl2
Summary
InnateDB Gene IDBG-160703.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh3gl2
Gene Name SH3-domain GRB2-like 2
Synonyms 9530001L19Rik; AI120490; AW555077; B930049H17Rik; EEN-B1; Sh3d2a; SH3PA
Species Mus musculus
Ensembl Gene ENSMUSG00000028488
Encoded Proteins
IDBP-160705
SH3-domain GRB2-like 2
IDBP-267205
SH3-domain GRB2-like 2
IDBP-267207
SH3-domain GRB2-like 2
IDBP-267211
SH3-domain GRB2-like 2
IDBP-534009
SH3-domain GRB2-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107295:
Gene Information
Type Protein coding
Genomic Location Chromosome 4:85205126-85639195
Strand Forward strand
Band C4
Transcripts
ENSMUST00000030212 ENSMUSP00000030212
ENSMUST00000107189 ENSMUSP00000102807
ENSMUST00000107188 ENSMUSP00000102806
ENSMUST00000107184 ENSMUSP00000102802
ENSMUST00000133109 ENSMUSP00000117573
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0042802 identical protein binding
Biological Process
GO:0002090 regulation of receptor internalization
GO:0048488 synaptic vesicle endocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000107295
View Gene Order
ENSBTAG00000014103
Not yet available
Pathways
NETPATH
REACTOME
REACT_203917
EGFR downregulation pathway
REACT_189085
Disease pathway
REACT_257923
Recycling pathway of L1 pathway
REACT_209837
Membrane Trafficking pathway
REACT_231722
Lysosome Vesicle Biogenesis pathway
REACT_230745
Immune System pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_202778
Retrograde neurotrophin signalling pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_242976
Signaling by EGFR pathway
REACT_261444
Axon guidance pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_219680
L1CAM interactions pathway
REACT_234979
Clathrin derived vesicle budding pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_188576
Developmental Biology pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_188257
Signal Transduction pathway
REACT_188180
Signaling by EGFR in Cancer pathway
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_12435
Retrograde neurotrophin signalling pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
erbb1_internalization_pathway
Internalization of ErbB1
rhoa_pathway
RhoA signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.409309
RefSeq NM_019535 XM_006537710
OMIM
CCDS CCDS18303
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca