InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pim1

Summary

InnateDB Gene

IDBG-160725.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pim1

Gene Name

proviral integration site 1

Synonyms

Pim-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024014

Encoded Proteins

IDBP-160727

proviral integration site 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137193:
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:29490812-29496111

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000024811

ENSMUSP00000024811

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0030145	manganese ion binding
GO:0043024	ribosomal small subunit binding

Biological Process

GO:0006468	protein phosphorylation
GO:0008283	cell proliferation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0030212	hyaluronan metabolic process
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0043066	negative regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000137193

View Gene Order

ENSBTAG00000000396

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04630

Jak-STAT signaling pathway pathway

mmu05221

Acute myeloid leukemia pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05221

Acute myeloid leukemia pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

myc_activpathway

Validated targets of C-MYC transcriptional activation

cmyb_pathway

C-MYB transcription factor network

il3_pathway

IL3-mediated signaling events

nfat_3pathway

Role of Calcineurin-dependent NFAT signaling in lymphocytes

gmcsf_pathway

GMCSF-mediated signaling events

il5_pathway

IL5-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.485038

RefSeq

NM_008842

OMIM

CCDS

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas