InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dad1

Summary

InnateDB Gene

IDBG-160827.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dad1

Gene Name

defender against cell death 1

Synonyms

AI323713

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022174

Encoded Proteins

IDBP-160829

defender against cell death 1

IDBP-537646

defender against cell death 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129562:
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:54235479-54254104

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022781	ENSMUSP00000022781
ENSMUST00000128231	ENSMUSP00000122366

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004576	oligosaccharyl transferase activity
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity

Biological Process

GO:0001824	blastocyst development
GO:0006486	protein glycosylation
GO:0006915	apoptotic process
GO:0007584	response to nutrient
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0008250	oligosaccharyltransferase complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000129562

View Gene Order

ENSBTAG00000019077

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00510

N-Glycan biosynthesis pathway

mmu04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22426

Asparagine N-linked glycosylation pathway

REACT_22161

Post-translational protein modification pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa00510

N-Glycan biosynthesis pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.319038

RefSeq

NM_001113358 NM_010015

OMIM

CCDS

CCDS27084

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas