InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dguok

Summary

InnateDB Gene

IDBG-161142.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dguok

Gene Name

deoxyguanosine kinase

Synonyms

dGK; dGK1; dGK2; dGK3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000014554

Encoded Proteins

IDBP-161146

deoxyguanosine kinase

IDBP-252952

deoxyguanosine kinase

IDBP-789393

deoxyguanosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114956:
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:83480217-83506969

Strand

Reverse strand

Band

Transcripts

ENSMUST00000014698	ENSMUSP00000014698
ENSMUST00000113888	ENSMUSP00000109520
ENSMUST00000145455	ENSMUSP00000138197
ENSMUST00000138941
ENSMUST00000153415
ENSMUST00000147060

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004138	deoxyguanosine kinase activity
GO:0005524	ATP binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006468	protein phosphorylation
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process
GO:0009165	nucleotide biosynthetic process
GO:0010977	negative regulation of neuron projection development
GO:0046070	dGTP metabolic process
GO:0046122	purine deoxyribonucleoside metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000114956

View Gene Order

ENSBTAG00000012037

Not yet available

Pathways

NETPATH

REACTOME

REACT_263730

Purine metabolism pathway

REACT_188937

Metabolism pathway

REACT_244050

Purine salvage pathway

REACT_245662

Metabolism of nucleotides pathway

KEGG

mmu00230

Purine metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_1923

Purine salvage pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_522

Purine metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00230

Purine metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001162521 NM_013764

OMIM

CCDS

CCDS20279 CCDS51821

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas