InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbxl5

Summary

InnateDB Gene

IDBG-161237.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxl5

Gene Name

F-box and leucine-rich repeat protein 5

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039753

Encoded Proteins

IDBP-161239

F-box and leucine-rich repeat protein 5

IDBP-161241

F-box and leucine-rich repeat protein 5

IDBP-252586

F-box and leucine-rich repeat protein 5

IDBP-401016

F-box and leucine-rich repeat protein 5

IDBP-401015

F-box and leucine-rich repeat protein 5

IDBP-539572

F-box and leucine-rich repeat protein 5

IDBP-539270

F-box and leucine-rich repeat protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118564:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:43744616-43821639

Strand

Reverse strand

Band

Transcripts

ENSMUST00000047857	ENSMUSP00000045792
ENSMUST00000087465	ENSMUSP00000084733
ENSMUST00000114047	ENSMUSP00000109681
ENSMUST00000119523	ENSMUSP00000113557
ENSMUST00000121736	ENSMUSP00000112444
ENSMUST00000141902	ENSMUSP00000120338
ENSMUST00000124610	ENSMUSP00000116720
ENSMUST00000140469
ENSMUST00000143316
ENSMUST00000124421

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding

Biological Process

GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0055072	iron ion homeostasis

Cellular Component

GO:0019005	SCF ubiquitin ligase complex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000118564

View Gene Order

ENSBTAG00000021214

Not yet available

Pathways

NETPATH

REACTOME

REACT_258900

Chaperonin-mediated protein folding pathway

REACT_244970

Association of TriC/CCT with target proteins during biosynthesis pathway

REACT_247926

Metabolism of proteins pathway

REACT_245534

Protein folding pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_16907

Association of TriC/CCT with target proteins during biosynthesis pathway

REACT_16952

Protein folding pathway

REACT_17004

Chaperonin-mediated protein folding pathway

REACT_17015

Metabolism of proteins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.25794 Mm.456609 Mm.457823

RefSeq

NM_001159963 NM_178729

OMIM

CCDS

CCDS19263 CCDS51489

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas