Version 5.4
| Mus musculus Gene: Creb1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-161359.6 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | Creb1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Name | cAMP responsive element binding protein 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms | 2310001E10Rik; 3526402H21Rik; AV083133; Creb; Creb-1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000025958 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
cAMP responsive element binding protein 1
cAMP responsive element binding protein 1
cAMP responsive element binding protein 1
cAMP responsive element binding protein 1
cAMP responsive element binding protein 1
cAMP responsive element binding protein 1
cAMP responsive element binding protein 1
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| Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
Creb1 over-expression in myeloid cells results in increased abscess formation and aberrant cytokine response.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] CREB1 and AP1 transcription factor activation regulates LPS- or M-CSF-induced activation of the MAPK phosphatase-1 (MKP-1) gene, a protein phosphatase that plays a crucial role in innate immunity.
[Homo sapiens] CREB1 has a key role in transcriptional regulation of macrophage migration inhibitory factor (MIF) gene expression and MIF-dependent host antimicrobial innate immune defence.
[Homo sapiens] CREB1 and CEBPB are involved in cytokine production in neutrophils in response to LPS and TNF.
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| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118260:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 1:64532645-64604548 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Band | C2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 181 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| REACTOME |
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Organelle biogenesis and maintenance pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
PI3K/AKT activation pathway
Disease pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
Signaling by GPCR pathway
Ca-dependent events pathway
MyD88 cascade initiated on plasma membrane pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
PLC-gamma1 signalling pathway
PKA-mediated phosphorylation of CREB pathway
PIP3 activates AKT signaling pathway
CREB phosphorylation through the activation of Adenylate Cyclase pathway
NOTCH2 intracellular domain regulates transcription pathway
CREB phosphorylation through the activation of Ras pathway
CREB phosphorylation through the activation of CaMKII pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
EGFR interacts with phospholipase C-gamma pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Post NMDA receptor activation events pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
CaMK IV-mediated phosphorylation of CREB pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
CREB phosphorylation through the activation of CaMKK pathway
CaM pathway pathway
CREB phosphorylation pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
AKT phosphorylates targets in the nucleus pathway
Signaling by EGFR pathway
Signaling by NOTCH2 pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Phospholipase C-mediated cascade pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Transcriptional activation of mitochondrial biogenesis pathway
Toll-Like Receptors Cascades pathway
PI3K/AKT Signaling in Cancer pathway
MyD88 dependent cascade initiated on endosome pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
Neuronal System pathway
Developmental Biology pathway
GAB1 signalosome pathway
Activated TLR4 signalling pathway
DAG and IP3 signaling pathway
NGF signalling via TRKA from the plasma membrane pathway
Opioid Signalling pathway
Calmodulin induced events pathway
MyD88-independent cascade pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Mitochondrial biogenesis pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Transmission across Chemical Synapses pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Signaling by FGFR pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Signaling by NOTCH pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Signaling by EGFR in Cancer pathway
NCAM signaling for neurite out-growth pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Nuclear Events (kinase and transcription factor activation) pathway
DAP12 interactions pathway
DAP12 signaling pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Antigen processing and presentation pathway
Melanogenesis pathway
Prostate cancer pathway
Circadian rhythm pathway
Huntington's disease pathway
Vasopressin-regulated water reabsorption pathway
Osteoclast differentiation pathway
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| INOH |
GPCR Adenosine A2A receptor signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH |
AndrogenReceptor pathway
EGFR1 pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
RANKL pathway
Leptin pathway
TSH pathway
FSH pathway
IL11 pathway
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| REACTOME |
AKT phosphorylates targets in the nucleus pathway
PIP3 activates AKT signaling pathway
PKA-mediated phosphorylation of CREB pathway
CaMK IV-mediated phosphorylation of CREB pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
CREB phosphorylation pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
PI3K/AKT activation pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
PLC beta mediated events pathway
Opioid Signalling pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K events in ERBB2 signaling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Circadian Clock pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
CREB phosphorylation through the activation of Adenylate Cyclase pathway
CREB phosphorylation through the activation of Ras pathway
CREB phosphorylation through the activation of CaMKK pathway
CREB phosphorylation through the activation of CaMKII pathway
NCAM signaling for neurite out-growth pathway
Signaling by FGFR in disease pathway
Organelle biogenesis and maintenance pathway
Developmental Biology pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Neuronal System pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Mitochondrial biogenesis pathway
Signaling by GPCR pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
Post NMDA receptor activation events pathway
G-protein mediated events pathway
Signaling by NOTCH2 pathway
Adaptive Immune System pathway
Immune System pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
Transcriptional activation of mitochondrial biogenesis pathway
NGF signalling via TRKA from the plasma membrane pathway
Signaling by NOTCH pathway
Transmission across Chemical Synapses pathway
Activated TLR4 signalling pathway
PI3K/AKT Signaling in Cancer pathway
Nuclear Events (kinase and transcription factor activation) pathway
NOTCH2 intracellular domain regulates transcription pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Signaling by the B Cell Receptor (BCR) pathway
Ca-dependent events pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
DAP12 interactions pathway
Signaling by EGFR pathway
PLCG1 events in ERBB2 signaling pathway
GAB1 signalosome pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Post NMDA receptor activation events pathway
NCAM signaling for neurite out-growth pathway
PKA-mediated phosphorylation of CREB pathway
Signaling by GPCR pathway
Signaling by PDGF pathway
Activated TLR4 signalling pathway
Calmodulin induced events pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
DAG and IP3 signaling pathway
MyD88-independent cascade pathway
Signaling by ERBB4 pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Transcriptional activation of mitochondrial biogenesis pathway
PLC-gamma1 signalling pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
AKT phosphorylates targets in the nucleus pathway
Signaling by FGFR pathway
CREB phosphorylation through the activation of Adenylate Cyclase pathway
CREB phosphorylation pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
PI3K events in ERBB2 signaling pathway
Immune System pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Transmission across Chemical Synapses pathway
EGFR interacts with phospholipase C-gamma pathway
MAP kinase activation in TLR cascade pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
Nuclear Events (kinase and transcription factor activation) pathway
CREB phosphorylation through the activation of CaMKII pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
Signaling by EGFR in Cancer pathway
G-protein mediated events pathway
PI-3K cascade pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Axon guidance pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
CaMK IV-mediated phosphorylation of CREB pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
CREB phosphorylation through the activation of Ras pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K events in ERBB4 signaling pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
PLC beta mediated events pathway
Downstream signaling of activated FGFR pathway
Neuronal System pathway
Signalling by NGF pathway
PI3K/AKT Signaling in Cancer pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Adaptive Immune System pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Phospholipase C-mediated cascade pathway
MyD88 dependent cascade initiated on endosome pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
Downstream signal transduction pathway
Opioid Signalling pathway
PIP3 activates AKT signaling pathway
Signaling by SCF-KIT pathway
CREB phosphorylation through the activation of CaMKK pathway
Innate Immune System pathway
PI3K/AKT activation pathway
Ca-dependent events pathway
CaM pathway pathway
Mitochondrial biogenesis pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
MyD88 cascade initiated on plasma membrane pathway
Developmental Biology pathway
Organelle biogenesis and maintenance pathway
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| KEGG |
Antigen processing and presentation pathway
Circadian rhythm pathway
Prostate cancer pathway
Melanogenesis pathway
Huntington's disease pathway
Vasopressin-regulated water reabsorption pathway
Osteoclast differentiation pathway
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| INOH |
GPCR Adenosine A2A receptor signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
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| PID NCI |
Trk receptor signaling mediated by PI3K and PLC-gamma
FOXA2 and FOXA3 transcription factor networks
Nongenotropic Androgen signaling
Trk receptor signaling mediated by the MAPK pathway
VEGFR3 signaling in lymphatic endothelium
ErbB1 downstream signaling
ATF-2 transcription factor network
Validated targets of C-MYC transcriptional repression
LKB1 signaling events
Integrin-linked kinase signaling
AP-1 transcription factor network
Glucocorticoid receptor regulatory network
Regulation of nuclear SMAD2/3 signaling
HIF-1-alpha transcription factor network
Signaling mediated by p38-alpha and p38-beta
Signaling events regulated by Ret tyrosine kinase
LPA4-mediated signaling events
p38 signaling mediated by MAPKAP kinases
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| Cross-References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniGene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001037726 NM_009952 NM_133828 XM_006495650 XM_006495651 XM_006495652 XM_006495653 XM_006495654 XM_006495655 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCDS | CCDS15004 CCDS15005 CCDS48280 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||