InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL7R

Summary

InnateDB Gene

IDBG-16161.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL7R

Gene Name

interleukin 7 receptor

Synonyms

CD127; CDW127; IL-7R-alpha; IL7RA; ILRA

Species

Homo sapiens

Ensembl Gene

ENSG00000168685

Encoded Proteins

IDBP-16163

interleukin 7 receptor

IDBP-474317

interleukin 7 receptor

IDBP-483233

interleukin 7 receptor

IDBP-484846

interleukin 7 receptor

IDBP-479375

interleukin 7 receptor

IDBP-481560

interleukin 7 receptor

IDBP-484149

interleukin 7 receptor

IDBP-485153

interleukin 7 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26187413

Differentiation of Type 3 innate lymphoid cells (ILC3) to IL7R(+) ILC1 is reversible whereas IL7R(+) ILC1 can differentiate to ILC3 in the presence of IL2, IL23A, and IL1B dependent on the transcription factor RORC, and this process is enhanced in the presence of retinoic acid.

Entrez Gene

Summary

The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:35852695-35879603

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000303115	ENSP00000306157
ENST00000508941	ENSP00000426426
ENST00000511031
ENST00000515665	ENSP00000425538
ENST00000514217	ENSP00000427688
ENST00000506850	ENSP00000421207
ENST00000511982	ENSP00000425309
ENST00000509668
ENST00000505093	ENSP00000426069
ENST00000505875	ENSP00000420923

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 127 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	127 [view]
Protein-Protein	121 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0004896	cytokine receptor activity
GO:0004917	interleukin-7 receptor activity
GO:0005515	protein binding

Biological Process

GO:0000018	regulation of DNA recombination
GO:0000902	cell morphogenesis
GO:0001915	negative regulation of T cell mediated cytotoxicity
GO:0002377	immunoglobulin production
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0008361	regulation of cell size
GO:0010628	positive regulation of gene expression
GO:0016049	cell growth
GO:0019221	cytokine-mediated signaling pathway
GO:0030217	T cell differentiation
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0038111	interleukin-7-mediated signaling pathway
GO:0042100	B cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0048535	lymph node development
GO:0048872	homeostasis of number of cells

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000003882

View Gene Order

ENSBTAG00000019975

Not yet available

Pathways

NETPATH

NetPath_6

KitReceptor pathway

NetPath_19

IL-7 pathway

NetPath_24

TSLP pathway

REACTOME

REACT_115529

Interleukin-7 signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_6900

Immune System pathway

REACT_22232

Signaling by Interleukins pathway

KEGG

hsa04640

Hematopoietic cell lineage pathway

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

hsa05340

Primary immunodeficiency pathway

INOH

INOH website

IL-7 signaling pathway

INOH website

JAK STAT pathway and regulation pathway

PID NCI

Cross-References

SwissProt

P16871

TrEMBL

B8YG18 D6RCR9 D6RDM4 D6RG28 D6RGV2 D9N160 H0Y8G3 H0YA41

UniProt Splice Variant

Entrez Gene

3575

UniGene

Hs.591742 Hs.619102 Hs.715147

RefSeq

NM_002185 XM_005248300

HUGO

HGNC:6024

OMIM

146661

CCDS

CCDS3911

HPRD

IMGT

EMBL

AC112204 AF043123 AF043124 AF043125 AF043126 AF043127 AF043128 AF043129 AK301220 AK315251 AY449709 BC020717 BC067537 BC067538 BC067539 BC067540 BC069999 FJ529208 M29696

GenPept

AAA59157 AAC83204 AAH20717 AAH67537 AAH67538 AAH67539 AAH67540 AAH69999 AAR08908 ACL80333 BAG37673 BAG62793

RNA Seq Atlas

3575