Version 5.4
Homo sapiens Gene: NRG1
Summary
InnateDB Gene IDBG-16182.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRG1
Gene Name neuregulin 1
Synonyms ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1-IT2; SMDF
Species Homo sapiens
Ensembl Gene ENSG00000157168
Encoded Proteins
IDBP-16186
neuregulin 1
IDBP-16196
neuregulin 1
IDBP-294502
neuregulin 1
IDBP-479868
neuregulin 1
IDBP-483666
neuregulin 1
IDBP-599751
neuregulin 1
IDBP-480725
neuregulin 1
IDBP-483814
neuregulin 1
IDBP-473918
neuregulin 1
IDBP-596892
neuregulin 1
IDBP-598945
neuregulin 1
IDBP-598617
neuregulin 1
IDBP-477180
neuregulin 1
IDBP-484972
neuregulin 1
IDBP-485076
neuregulin 1
IDBP-590241
neuregulin 1
IDBP-810704
neuregulin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq, May 2009]
The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:31639386-32765040
Strand Forward strand
Band p12
Transcripts
ENST00000287842 ENSP00000287842
ENST00000356819 ENSP00000349275
ENST00000405005 ENSP00000384620
ENST00000518104 ENSP00000430053
ENST00000519301 ENSP00000429582
ENST00000520407 ENSP00000434640
ENST00000523534 ENSP00000429067
ENST00000523079 ENSP00000430120
ENST00000521670 ENSP00000428828
ENST00000518206 ENSP00000432052
ENST00000522569
ENST00000523041 ENSP00000433350
ENST00000520502 ENSP00000433289
ENST00000518084 ENSP00000428546
ENST00000522402 ENSP00000430862
ENST00000519240 ENSP00000428411
ENST00000523681
ENST00000539990 ENSP00000439276
ENST00000614767 ENSP00000483727
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003712 transcription cofactor activity
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005176 ErbB-2 class receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0030296 protein tyrosine kinase activator activity
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
GO:0030971 receptor tyrosine kinase binding
GO:0043125 ErbB-3 class receptor binding
Biological Process
GO:0000165 MAPK cascade
GO:0000902 cell morphogenesis
GO:0003161 cardiac conduction system development
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0007154 cell communication
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007399 nervous system development
GO:0007416 synapse assembly
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007626 locomotory behavior
GO:0008283 cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009790 embryo development
GO:0010001 glial cell differentiation
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0014032 neural crest cell development
GO:0016477 cell migration
GO:0021781 glial cell fate commitment
GO:0030307 positive regulation of cell growth
GO:0030879 mammary gland development
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038127 ERBB signaling pathway
GO:0042060 wound healing
GO:0042177 negative regulation of protein catabolic process
GO:0043496 regulation of protein homodimerization activity
GO:0043497 regulation of protein heterodimerization activity
GO:0043624 cellular protein complex disassembly
GO:0045087 innate immune response
GO:0045213 neurotransmitter receptor metabolic process
GO:0045595 regulation of cell differentiation
GO:0045785 positive regulation of cell adhesion
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048663 neuron fate commitment
GO:0051048 negative regulation of secretion
GO:0051155 positive regulation of striated muscle cell differentiation
GO:0051897 positive regulation of protein kinase B signaling
GO:0055007 cardiac muscle cell differentiation
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060379 cardiac muscle cell myoblast differentiation
GO:0060956 endocardial cell differentiation
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030424 axon
GO:0031594 neuromuscular junction
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062991
View Gene Order
ENSBTAG00000004150
Not yet available
Pathways
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_116005
SHC1 events in ERBB4 signaling pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_115662
Downregulation of ERBB2:ERBB3 signaling pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_115896
GRB7 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa04012
ErbB signaling pathway pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
erbb4_pathway
ErbB4 signaling events
glypican_1pathway
Glypican 1 network
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
erbb_network_pathway
ErbB receptor signaling network
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.691092
RefSeq NM_001159995 NM_001159996 NM_001159999 NM_001160001 NM_001160004 NM_001160008 NM_013956 NM_013957 NM_013959 NM_013960 NM_013962 NM_013964 XM_006716335
HUGO
OMIM
CCDS CCDS47836 CCDS55218 CCDS55219 CCDS6084 CCDS6085 CCDS6086 CCDS6087 CCDS75727
HPRD 00802
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca