Version 5.4
Mus musculus Gene: Lrsam1
Summary
InnateDB Gene IDBG-161846.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lrsam1
Gene Name leucine rich repeat and sterile alpha motif containing 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026792
Encoded Proteins
IDBP-161848
leucine rich repeat and sterile alpha motif containing 1
IDBP-254374
leucine rich repeat and sterile alpha motif containing 1
IDBP-532059
leucine rich repeat and sterile alpha motif containing 1
IDBP-541533
leucine rich repeat and sterile alpha motif containing 1
IDBP-533281
leucine rich repeat and sterile alpha motif containing 1
IDBP-532531
leucine rich repeat and sterile alpha motif containing 1
IDBP-540806
leucine rich repeat and sterile alpha motif containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148356:
This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:32925216-32961614
Strand Reverse strand
Band B
Transcripts
ENSMUST00000028132 ENSMUSP00000028132
ENSMUST00000113200 ENSMUSP00000108825
ENSMUST00000127321 ENSMUSP00000115830
ENSMUST00000133832 ENSMUSP00000117194
ENSMUST00000147528 ENSMUSP00000122877
ENSMUST00000124492 ENSMUSP00000118604
ENSMUST00000145578 ENSMUSP00000122711
ENSMUST00000145699
ENSMUST00000138015
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0015031 protein transport
GO:0030163 protein catabolic process
GO:0045806 negative regulation of endocytosis
GO:0046755 non-lytic virus budding
GO:0051865 protein autoubiquitination
GO:0070086 ubiquitin-dependent endocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000148356
View Gene Order
ENSBTAG00000012844
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.248037 Mm.490880
RefSeq NM_199302 XM_006497962 XM_006497963 XM_006497964 XM_006497965 XM_006497966 XM_006497967 XM_006497969 XM_006497970 XM_006497971 XM_006497972
OMIM
CCDS CCDS15935
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca