InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dmc1

Summary

InnateDB Gene

IDBG-162059.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dmc1

Gene Name

DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination

Synonyms

Dmc1h; Lim15; Mei11; sgdp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022429

Encoded Proteins

IDBP-162061

DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. In mouse, deficiency of this gene causes infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:79561500-79605084

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023065

ENSMUSP00000023065

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	0
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000150	recombinase activity
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0001541	ovarian follicle development
GO:0001556	oocyte maturation
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006281	DNA repair
GO:0007129	synapsis
GO:0007131	reciprocal meiotic recombination
GO:0007141	male meiosis I
GO:0007276	gamete generation
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0009432	SOS response

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000794	condensed nuclear chromosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000100206

View Gene Order

ENSBTAG00000005936

Not yet available

Pathways

NETPATH

REACTOME

REACT_27235

Meiotic Recombination pathway

REACT_200794

Mus musculus biological processes pathway

REACT_188804

Cell Cycle pathway

REACT_198624

Meiosis pathway

REACT_198629

Meiotic recombination pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_27271

Meiotic recombination pathway

REACT_115566

Cell Cycle pathway

REACT_111183

Meiosis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q61880

TrEMBL

Q14AN8

UniProt Splice Variant

Entrez Gene

13404

UniGene

Mm.2524 Mm.473253

RefSeq

NM_010059

OMIM

CCDS

CCDS27644

HPRD

IMGT

MGI ID

MGI:105393

MGI Symbol

Dmc1

EMBL

BC116767 BC119081 CH466550 D58419 D64107

GenPept

AAI16768 AAI19082 BAA09590 BAA10969 EDL04643

RNA Seq Atlas

13404