InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pikfyve

Summary

InnateDB Gene

IDBG-162151.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pikfyve

Gene Name

phosphoinositide kinase, FYVE finger containing

Synonyms

5230400C17Rik; p235; Pip5k; Pip5k3; Pipk5k3; PipkIII

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025949

Encoded Proteins

IDBP-162153

phosphoinositide kinase, FYVE finger containing

IDBP-162835

phosphoinositide kinase, FYVE finger containing

IDBP-788250

phosphoinositide kinase, FYVE finger containing

IDBP-788252

phosphoinositide kinase, FYVE finger containing

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115020:
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:65186683-65278695

Strand

Forward strand

Band

Transcripts

ENSMUST00000081154	ENSMUSP00000079926
ENSMUST00000097707	ENSMUSP00000095314
ENSMUST00000185317
ENSMUST00000190058	ENSMUSP00000140204
ENSMUST00000188799
ENSMUST00000187579
ENSMUST00000189925
ENSMUST00000186404
ENSMUST00000185263	ENSMUSP00000140932
ENSMUST00000190847

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016307	phosphatidylinositol phosphate kinase activity
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0046872	metal ion binding
GO:0052810	1-phosphatidylinositol-5-kinase activity

Biological Process

GO:0032288	myelin assembly
GO:0034504	protein localization to nucleus
GO:0035556	intracellular signal transduction
GO:0042147	retrograde transport, endosome to Golgi
GO:0044267	cellular protein metabolic process
GO:0046488	phosphatidylinositol metabolic process
GO:0046854	phosphatidylinositol phosphorylation

Cellular Component

GO:0000139	Golgi membrane
GO:0005829	cytosol
GO:0005911	cell-cell junction
GO:0010008	endosome membrane
GO:0012506	vesicle membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0031901	early endosome membrane
GO:0031902	late endosome membrane
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm