Version 5.4
| Mus musculus Gene: Ptpn21 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-162482.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Ptpn21 | ||||||||
| Gene Name | protein tyrosine phosphatase, non-receptor type 21 | ||||||||
| Synonyms | PTPD1; PTPRL10 | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000021009 | ||||||||
| Encoded Proteins |
protein tyrosine phosphatase, non-receptor type 21
protein tyrosine phosphatase, non-receptor type 21
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070778:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 12:98676741-98737405 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | E | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG | |||||||||
| INOH | |||||||||
| PID NCI |
Signaling events mediated by focal adhesion kinase
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | G5E8J4 Q78VI1 Q9QWQ7 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 24000 | ||||||||
| UniGene | Mm.394539 Mm.407619 Mm.4420 | ||||||||
| RefSeq | NM_001146199 NM_011877 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS26098 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1344406 | ||||||||
| MGI Symbol | Ptpn21 | ||||||||
| EMBL | AC124516 AC159193 AK030456 CH466549 D83072 | ||||||||
| GenPept | BAA19740 BAC26970 EDL18927 EDL18928 EDL18929 | ||||||||
| RNA Seq Atlas | 24000 | ||||||||