Version 5.4
Mus musculus Gene: Cope
Summary
InnateDB Gene IDBG-162492.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cope
Gene Name coatomer protein complex, subunit epsilon
Synonyms 1110005D17Rik; Cope1
Species Mus musculus
Ensembl Gene ENSMUSG00000055681
Encoded Proteins
IDBP-162494
coatomer protein complex, subunit epsilon
IDBP-539113
coatomer protein complex, subunit epsilon
IDBP-531785
coatomer protein complex, subunit epsilon
IDBP-620606
coatomer protein complex, subunit epsilon
IDBP-620607
coatomer protein complex, subunit epsilon
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105669:
The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta\', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:70302518-70312993
Strand Forward strand
Band B3.3
Transcripts
ENSMUST00000066469 ENSMUSP00000071078
ENSMUST00000140363
ENSMUST00000134822
ENSMUST00000150968 ENSMUSP00000119055
ENSMUST00000128822
ENSMUST00000128003 ENSMUSP00000122888
ENSMUST00000168018 ENSMUSP00000130416
ENSMUST00000167850 ENSMUSP00000132976
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0030137 COPI-coated vesicle
GO:0030663 COPI-coated vesicle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105669
View Gene Order
ENSBTAG00000000810
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_207127
Golgi to ER Retrograde Transport pathway
REACT_227904
COPI Mediated Transport pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11096
COPI Mediated Transport pathway
REACT_11208
Golgi to ER Retrograde Transport pathway
REACT_11123
Membrane Trafficking pathway
REACT_211733
Golgi to ER Retrograde Transport pathway
REACT_206224
COPI Mediated Transport pathway
REACT_213260
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28668
RefSeq NM_021538
OMIM
CCDS CCDS22365
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca