InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyp26b1

Summary

InnateDB Gene

IDBG-162650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp26b1

Gene Name

cytochrome P450, family 26, subfamily b, polypeptide 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000063415

Encoded Proteins

IDBP-162654

cytochrome P450, family 26, subfamily b, polypeptide 1

IDBP-620292

cytochrome P450, family 26, subfamily b, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000003137:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:84571414-84593908

Strand

Reverse strand

Band

Transcripts

ENSMUST00000077705	ENSMUSP00000076886
ENSMUST00000168003	ENSMUSP00000128391

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0005506	iron ion binding
GO:0008401	retinoic acid 4-hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0001709	cell fate determination
GO:0007140	male meiosis
GO:0007283	spermatogenesis
GO:0009954	proximal/distal pattern formation
GO:0010628	positive regulation of gene expression
GO:0030326	embryonic limb morphogenesis
GO:0034653	retinoic acid catabolic process
GO:0042573	retinoic acid metabolic process
GO:0043587	tongue morphogenesis
GO:0048384	retinoic acid receptor signaling pathway
GO:0048387	negative regulation of retinoic acid receptor signaling pathway
GO:0055114	oxidation-reduction process
GO:0060349	bone morphogenesis
GO:0061436	establishment of skin barrier
GO:0070268	cornification
GO:0071300	cellular response to retinoic acid
GO:2001037	positive regulation of tongue muscle cell differentiation