Mus musculus Gene: Cd200
Summary
InnateDB Gene IDBG-162936.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd200
Gene Name CD200 antigen
Synonyms Mox2; OX2
Species Mus musculus
Ensembl Gene ENSMUSG00000022661
Encoded Proteins
CD200 antigen
CD200 antigen
CD200 antigen
CD200 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Cd200-Cd200r1 pathway is an important regulator of antiviral immunity during cytomegalovirus infection that is exploited by murine cytomegalovirus to establish chronicity within mucosal tissue.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] CD200 is induced by TLR-, NOD2-, and NALP3-mediated pathways, limiting macrophage activation and protecting the host from excessive inflammation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091972:
The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:45382135-45409053
Strand Reverse strand
Band B5
Transcripts
ENSMUST00000023341 ENSMUSP00000023341
ENSMUST00000163230 ENSMUSP00000130518
ENSMUST00000171328
ENSMUST00000167355 ENSMUSP00000132506
ENSMUST00000166512 ENSMUSP00000129541
ENSMUST00000171855
ENSMUST00000165910
ENSMUST00000166630
ENSMUST00000167552
ENSMUST00000172297
ENSMUST00000172091
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q80VX2
UniProt Splice Variant
Entrez Gene 17470
UniGene Mm.245851 Mm.415782
RefSeq NM_010818
OMIM
CCDS CCDS49860
HPRD
IMGT
MGI ID MGI:1196990
MGI Symbol Cd200
EMBL AC117686 AC117783 BC051984 BC054759
GenPept AAH51984 AAH54759
RNA Seq Atlas 17470