Version 5.4
Mus musculus Gene: Mapkap1
Summary
InnateDB Gene IDBG-162945.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mapkap1
Gene Name mitogen-activated protein kinase associated protein 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000038696
Encoded Proteins
IDBP-162947
mitogen-activated protein kinase associated protein 1
IDBP-254535
mitogen-activated protein kinase associated protein 1
IDBP-254537
mitogen-activated protein kinase associated protein 1
IDBP-254539
mitogen-activated protein kinase associated protein 1
IDBP-533252
mitogen-activated protein kinase associated protein 1
IDBP-533499
mitogen-activated protein kinase associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119487:
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:34406771-34624950
Strand Forward strand
Band B
Transcripts
ENSMUST00000040459 ENSMUSP00000035451
ENSMUST00000113126 ENSMUSP00000108751
ENSMUST00000113124 ENSMUSP00000108749
ENSMUST00000113123 ENSMUSP00000108748
ENSMUST00000149383
ENSMUST00000124443 ENSMUSP00000123301
ENSMUST00000141253
ENSMUST00000156967
ENSMUST00000147337 ENSMUSP00000116494
ENSMUST00000138933
ENSMUST00000137021
ENSMUST00000129633
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0017016 Ras GTPase binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0070300 phosphatidic acid binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Biological Process
GO:0006950 response to stress
GO:0021762 substantia nigra development
GO:0046580 negative regulation of Ras protein signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000119487
View Gene Order
ENSBTAG00000010271
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_226151
CD28 dependent PI3K/Akt signaling pathway
REACT_189085
Disease pathway
REACT_227951
Signaling by VEGF pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_242976
Signaling by EGFR pathway
REACT_204081
CD28 co-stimulation pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_261840
VEGFR2 mediated vascular permeability pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_206286
GAB1 signalosome pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_19358
CD28 dependent PI3K/Akt signaling pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_12529
Signaling by VEGF pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_217956
DAP12 interactions pathway
REACT_217559
CD28 dependent PI3K/Akt signaling pathway
REACT_208036
Signaling by EGFR pathway
REACT_222082
GAB1 signalosome pathway
REACT_204365
Signaling by PDGF pathway
REACT_216183
Signaling by ERBB4 pathway
REACT_213843
Costimulation by the CD28 family pathway
REACT_202837
Signaling by FGFR pathway
REACT_246299
VEGFA-VEGFR2 Pathway pathway
REACT_215558
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_219416
PI3K events in ERBB2 signaling pathway
REACT_213138
Immune System pathway
REACT_215895
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_224780
CD28 co-stimulation pathway
REACT_205435
Signaling by the B Cell Receptor (BCR) pathway
REACT_218958
Signaling by ERBB2 pathway
REACT_214353
Signal Transduction pathway
REACT_236208
VEGFR2 mediated vascular permeability pathway
REACT_221368
Signaling by EGFR in Cancer pathway
REACT_204467
PI-3K cascade pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_222492
PI3K events in ERBB4 signaling pathway
REACT_206613
Downstream signaling of activated FGFR pathway
REACT_207066
Signalling by NGF pathway
REACT_226693
Signaling by VEGF pathway
REACT_221870
PI3K/AKT Signaling in Cancer pathway
REACT_224097
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_214469
Adaptive Immune System pathway
REACT_212750
Downstream signal transduction pathway
REACT_208171
PIP3 activates AKT signaling pathway
REACT_204114
Signaling by SCF-KIT pathway
REACT_216714
Innate Immune System pathway
REACT_225332
PI3K/AKT activation pathway
REACT_214988
DAP12 signaling pathway
REACT_207087
Disease pathway
REACT_203736
Signaling by FGFR in disease pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
KEGG
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
cxcr4_pathway
CXCR4-mediated signaling events
erbb1_downstream_pathway
ErbB1 downstream signaling
mtor_4pathway
mTOR signaling pathway
cxcr3pathway
CXCR3-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001290625 NM_001290626 NM_177345 XM_006497973 XM_006497975 XM_006497976 XM_006497981 XM_006497982 XM_006497983
OMIM
CCDS CCDS15948 CCDS71035
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca