Version 5.4
Mus musculus Gene: Pts
Summary
InnateDB Gene IDBG-163351.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pts
Gene Name 6-pyruvoyl-tetrahydropterin synthase
Synonyms PTPS
Species Mus musculus
Ensembl Gene ENSMUSG00000032067
Encoded Proteins
IDBP-163353
6-pyruvoyl-tetrahydropterin synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150787:
The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:50521618-50528641
Strand Reverse strand
Band A5.3
Transcripts
ENSMUST00000034570 ENSMUSP00000034570
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003874 6-pyruvoyltetrahydropterin synthase activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006729 tetrahydrobiopterin biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000150787
View Gene Order
ENSBTAG00000003770
Not yet available
Pathways
NETPATH
REACTOME
REACT_199047
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_204801
eNOS activation and regulation pathway
REACT_188937
Metabolism pathway
REACT_208364
Metabolism of nitric oxide pathway
KEGG
mmu00790
Folate biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111176
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_12389
eNOS activation and regulation pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_111217
Metabolism pathway
KEGG
hsa00790
Folate biosynthesis pathway
INOH
INOH website
Folate metabolism pathway
PID NCI
Cross-References
SwissProt Q9R1Z7
TrEMBL
UniProt Splice Variant
Entrez Gene 19286
UniGene
RefSeq NM_011220
OMIM
CCDS CCDS23164
HPRD
IMGT
MGI ID MGI:1338783
MGI Symbol Pts
EMBL AF043225 AF061878 AF061879 AF061880 AK002614 AK146987 BC029013
GenPept AAD02249 AAD15827 AAH29013 BAB22231 BAE27590
RNA Seq Atlas 19286

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca