InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Muc1

Summary

InnateDB Gene

IDBG-163463.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Muc1

Gene Name

mucin 1, transmembrane

Synonyms

CD227; EMA; Muc-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000042784

Encoded Proteins

IDBP-163465

mucin 1, transmembrane

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21868711

Muc1 controls the inflammatory response in airway epithelial cells during nontypeable Haemophilus influenzae infection, mainly through suppression of Tlr2 signalling and decreased Il8 production.

InnateDB Annotation from Orthologs

Summary

PMID 20375631

[Homo sapiens] MUC1 regulates innate immune responses of dendritic cells (DC) where deletion of MUC1 promotes a heightened functional response of DC in response to TLR4 and TLR5 signalling pathways.

PMID 21868711

[Homo sapiens] MUC1 controls the inflammatory response in airway epithelial cells during nontypeable Haemophilus influenzae infection, mainly through suppression of TLR2 signalling and decreased IL8 production. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185499:
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:89229057-89233381

Strand

Forward strand

Band

Transcripts

ENSMUST00000041142	ENSMUSP00000041963
ENSMUST00000146844
ENSMUST00000139206

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0007565	female pregnancy
GO:0030855	epithelial cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane