Version 5.4
Mus musculus Gene: Cd226
Summary
InnateDB Gene IDBG-163478.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd226
Gene Name CD226 antigen
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000034028
Encoded Proteins
IDBP-163480
CD226 antigen
IDBP-163482
CD226 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150637:
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:89197431-89270201
Strand Forward strand
Band E4
Transcripts
ENSMUST00000037142 ENSMUSP00000043551
ENSMUST00000097496 ENSMUSP00000095104
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001816 cytokine production
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002891 positive regulation of immunoglobulin mediated immune response
GO:0007155 cell adhesion
GO:0033005 positive regulation of mast cell activation
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway
Cellular Component
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000150637
View Gene Order
Pathways
NETPATH
REACTOME
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_230745
Immune System pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt Q8K4F0
TrEMBL Q5DW69 Q8K4E2 Q8K4E3
UniProt Splice Variant
Entrez Gene 225825
UniGene Mm.139293
RefSeq NM_001039149 NM_178687 XM_006526461 XM_006526462
OMIM
CCDS CCDS29391 CCDS29392
HPRD
IMGT
MGI ID MGI:3039602
MGI Symbol Cd226
EMBL AB195429 AC116387 AF416980 AF421199 AF421200 AK140349 BC132422 BC138769 BC145410 CH466632
GenPept AAI32423 AAI38770 AAI45411 AAN04295 AAN04297 AAN04298 BAD90660 BAE24349 EDL00649
RNA Seq Atlas 225825

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca