InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abcg1

Summary

InnateDB Gene

IDBG-163644.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcg1

Gene Name

ATP-binding cassette, sub-family G (WHITE), member 1

Synonyms

Abc8; AW413978; White

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024030

Encoded Proteins

IDBP-163646

ATP-binding cassette, sub-family G (WHITE), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20395559

Abcg1 regulates innate immunity in a tissue-selective manner and Abcg1(-/-) mice have an enhanced pulmonary host defense response driven predominantly by hematopoietic cells.

InnateDB Annotation from Orthologs

Summary

PMID 20395559

[Homo sapiens] ABCG1 regulates innate immunity in a tissue-selective manner and Abcg1(-/-) mice have an enhanced pulmonary host defence response driven predominantly by hematopoietic cells.

Entrez Gene

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The human protein is involved in macrophage cholesterol efflux and may regulate cellular lipid homeostasis in other cell types. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:31057698-31115777

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000024829	ENSMUSP00000024829
ENSMUST00000139013

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005548	phospholipid transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0017127	cholesterol transporter activity
GO:0019534	toxin transporter activity
GO:0034041	sterol-transporting ATPase activity
GO:0034437	glycoprotein transporter activity
GO:0042803	protein homodimerization activity
GO:0043531	ADP binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0008203	cholesterol metabolic process
GO:0010033	response to organic substance
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010872	regulation of cholesterol esterification
GO:0010875	positive regulation of cholesterol efflux
GO:0010888	negative regulation of lipid storage
GO:0030301	cholesterol transport
GO:0032367	intracellular cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0033993	response to lipid
GO:0034374	low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0034436	glycoprotein transport
GO:0042632	cholesterol homeostasis
GO:0042987	amyloid precursor protein catabolic process
GO:0043691	reverse cholesterol transport
GO:0045087	innate immune response (InnateDB)
GO:0045542	positive regulation of cholesterol biosynthetic process
GO:0055091	phospholipid homeostasis
GO:0055099	response to high density lipoprotein particle stimulus
GO:1901998	toxin transport

Cellular Component

GO:0005739	mitochondrion
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0055037	recycling endosome