Version 5.4
Mus musculus Gene: Traf1
Summary
InnateDB Gene IDBG-163730.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Traf1
Gene Name TNF receptor-associated factor 1
Synonyms 4732496E14Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000026875
Encoded Proteins
IDBP-163732
TNF receptor-associated factor 1
IDBP-254672
TNF receptor-associated factor 1
IDBP-624537
TNF receptor-associated factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19698991
[Homo sapiens] TRAF1 is a positive regulator of the NF-kappaB alternative pathway.
PMID 19540595
[Homo sapiens] TRAF1 mediates both the CD30 signaling-dependent and independent NF-kappaB activation, which prevents lymphoma cells from spontaneous and induced apoptosis.
PMID 18429822
[Homo sapiens] TRAF1 phosphorylation by the ubiquitously expressed kinase PKN1 plays a critical role in the negative regulation of tonic activity of JNK and NF-kappaB signalling pathways.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000056558:
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:34941750-34961772
Strand Reverse strand
Band B
Transcripts
ENSMUST00000028234 ENSMUSP00000028234
ENSMUST00000113064 ENSMUSP00000108687
ENSMUST00000129131
ENSMUST00000141238
ENSMUST00000135870
ENSMUST00000156479
ENSMUST00000172159 ENSMUSP00000130759
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 80 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031625 ubiquitin protein ligase binding
GO:0031996 thioesterase binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0042981 regulation of apoptotic process
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:2001236 regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000056558
View Gene Order
ENSBTAG00000003012
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05222
Small cell lung cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
NetPath_21
RANKL pathway
NetPath_26
TWEAK pathway
REACTOME
KEGG
hsa05222
Small cell lung cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
cd40_pathway
CD40/CD40L signaling
tnfpathway
TNF receptor signaling pathway
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_009421 XM_006497843 XM_006497844 XM_006497845
OMIM
CCDS CCDS15956
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca