InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gabrb2

Summary

InnateDB Gene

IDBG-163739.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gabrb2

Gene Name

gamma-aminobutyric acid (GABA) A receptor, subunit beta 2

Synonyms

AI834970; C030002O17Rik; C030021G16Rik; Gabrab2; Gabrb-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000007653

Encoded Proteins

IDBP-163741

gamma-aminobutyric acid (GABA) A receptor, subunit beta 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145864:
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:42419757-42629028

Strand

Forward strand

Band

Transcripts

ENSMUST00000007797	ENSMUSP00000007797
ENSMUST00000140463
ENSMUST00000136050
ENSMUST00000143626

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005237	inhibitory extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0007165	signal transduction
GO:0007605	sensory perception of sound
GO:0034220	ion transmembrane transport
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0048666	neuron development
GO:0051932	synaptic transmission, GABAergic
GO:0060119	inner ear receptor cell development
GO:0060384	innervation
GO:0071420	cellular response to histamine
GO:0090102	cochlea development
GO:1901215	negative regulation of neuron death
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0034707	chloride channel complex
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome
GO:1902711	GABA-A receptor complex