Version 5.4
| Mus musculus Gene: Calm1 | |||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-163852.6 | ||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||
| Gene Symbol | Calm1 | ||||||||||||||||||||||||||||||||||||||
| Gene Name | calmodulin 1 | ||||||||||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000001175 | ||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
calmodulin 1
calmodulin 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||||||||||||||||
| Summary |
Calm1 (CaM) and Nos2 (iNOS) coordinately function to form a stable complex that is part of a rapid host response that functions within the first 30 min following bacterial infection to upregulate the innate immune system involving macrophage activation.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] CALM1 (CaM) and NOS2 (iNOS) coordinately function to form a stable complex that is part of a rapid host response that functions within the first 30 min following bacterial infection to upregulate the innate immune system involving macrophage activation.
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| Entrez Gene | |||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198668:
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 12:100199435-100209806 | ||||||||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||
| Band | E | ||||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 200 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||
| REACTOME |
Platelet degranulation pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
Innate Immune System pathway
Organelle biogenesis and maintenance pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Disease pathway
Hemostasis pathway
Signaling by Wnt pathway
eNOS activation and regulation pathway
Signaling by GPCR pathway
Membrane Trafficking pathway
Ionotropic activity of Kainate Receptors pathway
Activation of Kainate Receptors upon glutamate binding pathway
eNOS activation pathway
Ca-dependent events pathway
Signaling by VEGF pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Signaling by FGFR in disease pathway
DARPP-32 events pathway
beta-catenin independent WNT signaling pathway
Activation of Ca-permeable Kainate Receptor pathway
VEGFR2 mediated cell proliferation pathway
Smooth Muscle Contraction pathway
PLC-gamma1 signalling pathway
Glucose metabolism pathway
Metabolism pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
CREB phosphorylation through the activation of Ras pathway
CREB phosphorylation through the activation of CaMKII pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
EGFR interacts with phospholipase C-gamma pathway
Post NMDA receptor activation events pathway
CaMK IV-mediated phosphorylation of CREB pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
CREB phosphorylation through the activation of CaMKK pathway
CaM pathway pathway
Muscle contraction pathway
Signaling by EGFR pathway
Glycogen breakdown (glycogenolysis) pathway
Phospholipase C-mediated cascade pathway
VEGFR2 mediated vascular permeability pathway
VEGFA-VEGFR2 Pathway pathway
Cam-PDE 1 activation pathway
Fc epsilon receptor (FCERI) signaling pathway
Ca2+ pathway pathway
FCERI mediated Ca+2 mobilization pathway
Transcriptional activation of mitochondrial biogenesis pathway
Activation of CaMK IV pathway
Glycogen storage diseases pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
Neuronal System pathway
DAG and IP3 signaling pathway
Metabolism of nitric oxide pathway
NGF signalling via TRKA from the plasma membrane pathway
Opioid Signalling pathway
Response to elevated platelet cytosolic Ca2+ pathway
Calmodulin induced events pathway
Signal Transduction pathway
Inositol phosphate metabolism pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Mitochondrial biogenesis pathway
Transmission across Chemical Synapses pathway
Signaling by FGFR pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Myoclonic epilepsy of Lafora pathway
Signaling by EGFR in Cancer pathway
Translocation of GLUT4 to the plasma membrane pathway
Metabolism of carbohydrates pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Olfactory transduction pathway
Insulin signaling pathway pathway
Calcium signaling pathway pathway
Alzheimer's disease pathway
Melanogenesis pathway
Phosphatidylinositol signaling system pathway
GnRH signaling pathway pathway
Long-term potentiation pathway
Glioma pathway
Vascular smooth muscle contraction pathway
Neurotrophin signaling pathway pathway
Oocyte meiosis pathway
Phototransduction pathway
Gastric acid secretion pathway
Salivary secretion pathway
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| INOH | |||||||||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
TCR pathway
TSLP pathway
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| REACTOME |
Cam-PDE 1 activation pathway
CaMK IV-mediated phosphorylation of CREB pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
PLC beta mediated events pathway
DARPP-32 events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Activation of CaMK IV pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Glycogen breakdown (glycogenolysis) pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
eNOS activation pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
CREB phosphorylation through the activation of Ras pathway
CREB phosphorylation through the activation of CaMKK pathway
CREB phosphorylation through the activation of CaMKII pathway
Translocation of GLUT4 to the plasma membrane pathway
Smooth Muscle Contraction pathway
Signaling by FGFR in disease pathway
Organelle biogenesis and maintenance pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Ca2+ pathway pathway
Myoclonic epilepsy of Lafora pathway
beta-catenin independent WNT signaling pathway
eNOS activation and regulation pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by VEGF pathway
Mitochondrial biogenesis pathway
Metabolism of carbohydrates pathway
Signaling by GPCR pathway
Innate Immune System pathway
Metabolism of nitric oxide pathway
Ionotropic activity of Kainate Receptors pathway
Platelet activation, signaling and aggregation pathway
VEGFR2 mediated vascular permeability pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Post NMDA receptor activation events pathway
G-protein mediated events pathway
Activation of Kainate Receptors upon glutamate binding pathway
Adaptive Immune System pathway
Diseases associated with visual transduction pathway
Immune System pathway
VEGFR2 mediated cell proliferation pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
VEGFA-VEGFR2 Pathway pathway
Transcriptional activation of mitochondrial biogenesis pathway
NGF signalling via TRKA from the plasma membrane pathway
Visual phototransduction pathway
Transmission across Chemical Synapses pathway
Activation of Ca-permeable Kainate Receptor pathway
Muscle contraction pathway
Inositol phosphate metabolism pathway
The phototransduction cascade pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
FCERI mediated Ca+2 mobilization pathway
Signaling by the B Cell Receptor (BCR) pathway
Ca-dependent events pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
Hemostasis pathway
Membrane Trafficking pathway
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| KEGG |
GnRH signaling pathway pathway
Olfactory transduction pathway
Long-term potentiation pathway
Alzheimer's disease pathway
Glioma pathway
Phosphatidylinositol signaling system pathway
Insulin signaling pathway pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Vascular smooth muscle contraction pathway
Neurotrophin signaling pathway pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
Salivary secretion pathway
Phototransduction pathway
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| INOH |
CD4 T cell receptor signaling pathway
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| PID NCI |
Calcium signaling in the CD4+ TCR pathway
Cellular roles of Anthrax toxin
Downstream signaling in naïve CD8+ T cells
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
ErbB1 downstream signaling
BCR signaling pathway
Regulation of Ras family activation
Signaling events mediated by VEGFR1 and VEGFR2
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
VEGFR1 specific signals
Lissencephaly gene (LIS1) in neuronal migration and development
IL2 signaling events mediated by PI3K
Insulin-mediated glucose transport
N-cadherin signaling events
IFN-gamma pathway
p38 MAPK signaling pathway
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| Cross-References | |||||||||||||||||||||||||||||||||||||||
| SwissProt | P62204 | ||||||||||||||||||||||||||||||||||||||
| TrEMBL | G3UX57 | ||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||
| Entrez Gene | 12315 | ||||||||||||||||||||||||||||||||||||||
| UniGene | Mm.285993 Mm.471223 | ||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_009790 | ||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||
| CCDS | CCDS36523 | ||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||
| MGI ID | MGI:88251 | ||||||||||||||||||||||||||||||||||||||
| MGI Symbol | Calm1 | ||||||||||||||||||||||||||||||||||||||
| EMBL | AC165955 AK004673 AK012247 AK012564 AK013068 AK013695 AK083996 AK088141 AK150288 AK150978 AK151001 AK151552 AK151610 AK151784 AK151923 AK151992 AK152148 AK152303 AK152715 AK152719 AK152754 AK152850 AK152897 AK153004 AK153179 AK153348 AK153426 AK153546 AK159762 AK160057 AK160508 AK160636 AK161268 AK161302 AK161984 AK162314 AK166308 AK167353 AK168002 AK168241 AK168663 AK168741 AK168803 AK169027 AK169055 AK169640 AY902353 BC010730 BC021347 BC050926 BC051444 BC054805 BC100301 L31642 M19380 M19381 M27844 X61432 | ||||||||||||||||||||||||||||||||||||||
| GenPept | AAA37365 AAA65934 AAA66181 AAA66182 AAH10730 AAH21347 AAH50926 AAH51444 AAH54805 AAI00302 AAY21063 BAB23462 BAB28116 BAB28319 BAB28631 BAB28959 BAC39089 BAC40168 BAE29443 BAE30007 BAE30025 BAE30497 BAE30549 BAE30686 BAE30801 BAE30856 BAE30984 BAE31109 BAE31439 BAE31442 BAE31469 BAE31543 BAE31579 BAE31644 BAE31782 BAE31924 BAE31985 BAE32083 BAE35353 BAE35595 BAE35832 BAE35930 BAE36280 BAE36309 BAE36667 BAE36849 BAE38695 BAE39452 BAE39990 BAE40191 BAE40516 BAE40582 BAE40633 BAE40819 BAE40843 BAE41271 CAA43674 | ||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 12313 12314 12315 | ||||||||||||||||||||||||||||||||||||||