InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Smarcb1

Summary

InnateDB Gene

IDBG-164041.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smarcb1

Gene Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

Synonyms

AU020204; Baf47; Ini1; Snf5; SNF5/INI1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000902

Encoded Proteins

IDBP-164043

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

IDBP-401067

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

IDBP-532782

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

IDBP-541221

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099956:
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:75896769-75921617

Strand

Reverse strand

Band

Transcripts

ENSMUST00000000925	ENSMUSP00000000925
ENSMUST00000121304	ENSMUSP00000112463
ENSMUST00000133189
ENSMUST00000140408
ENSMUST00000140388	ENSMUSP00000123093
ENSMUST00000146555	ENSMUSP00000115388

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 127 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	127 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0002039	p53 binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0030957	Tat protein binding
GO:0031492	nucleosomal DNA binding

Biological Process

GO:0001824	blastocyst development
GO:0001835	blastocyst hatching
GO:0006281	DNA repair
GO:0006337	nucleosome disassembly
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0030154	cell differentiation
GO:0039692	single stranded viral RNA replication via double stranded DNA intermediate
GO:0043044	ATP-dependent chromatin remodeling
GO:0043923	positive regulation by host of viral transcription
GO:0044772	mitotic cell cycle phase transition
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0000228	nuclear chromosome
GO:0000790	nuclear chromatin
GO:0001741	XY body
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016514	SWI/SNF complex
GO:0043234	protein complex
GO:0071564	npBAF complex
GO:0071565	nBAF complex