InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Erbb4

Summary

InnateDB Gene

IDBG-164078.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Erbb4

Gene Name

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

Synonyms

c-erbB-4; Her4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000062209

Encoded Proteins

IDBP-401148

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

IDBP-401147

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

IDBP-536962

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178568:
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:68032186-69108059

Strand

Reverse strand

Band

Transcripts

ENSMUST00000121473	ENSMUSP00000114123
ENSMUST00000119142	ENSMUSP00000112713
ENSMUST00000153432	ENSMUSP00000115373
ENSMUST00000131148
ENSMUST00000126682

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004716	receptor signaling protein tyrosine kinase activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001755	neural crest cell migration
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399	nervous system development
GO:0007507	heart development
GO:0007595	lactation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009880	embryonic pattern specification
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021551	central nervous system morphogenesis
GO:0021889	olfactory bulb interneuron differentiation
GO:0023014	signal transduction by phosphorylation
GO:0030334	regulation of cell migration
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066	negative regulation of apoptotic process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0043653	mitochondrial fragmentation involved in apoptotic process
GO:0045165	cell fate commitment
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046777	protein autophosphorylation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060644	mammary gland epithelial cell differentiation
GO:0060749	mammary gland alveolus development
GO:0061026	cardiac muscle tissue regeneration
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:2000366	positive regulation of STAT protein import into nucleus

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0043235	receptor complex