Homo sapiens Gene: SKP2 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-16420.7 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | SKP2 | ||||||||||||||||||||||||
Gene Name | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | ||||||||||||||||||||||||
Synonyms | FBL1; FBXL1; FLB1; p45 | ||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000145604 | ||||||||||||||||||||||||
Encoded Proteins |
S-phase kinase-associated protein 2 (p45)
S-phase kinase-associated protein 2 (p45)
S-phase kinase-associated protein 2 (p45)
S-phase kinase-associated protein 2 (p45)
S-phase kinase-associated protein 2 (p45)
S-phase kinase-associated protein 2 (p45)
S-phase kinase-associated protein 2 (p45)
S-phase kinase-associated protein 2 (p45)
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||
Summary |
IFI27 restricts viral infection by recruiting an E3 ligase, SKP2, for ubiquitination and degradation of viral protein.
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Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 5:36151989-36184319 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | p13.2 | ||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 176 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH |
Notch pathway
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REACTOME |
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Cyclin E associated events during G1/S transition pathway
Cyclin D associated events in G1 pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
G1 Phase pathway
APC/C-mediated degradation of cell cycle proteins pathway
Regulation of mitotic cell cycle pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G1/S Transition pathway
Cell Cycle pathway
Adaptive Immune System pathway
Immune System pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
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KEGG |
Cell cycle pathway
Ubiquitin mediated proteolysis pathway
Small cell lung cancer pathway
Pathways in cancer pathway
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INOH | |||||||||||||||||||||||||
PID NCI |
Regulation of retinoblastoma protein
FoxO family signaling
p53 pathway
C-MYC pathway
FOXM1 transcription factor network
Notch signaling pathway
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Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 6502 | ||||||||||||||||||||||||
UniGene | |||||||||||||||||||||||||
RefSeq | NM_001243120 NM_005983 NM_032637 | ||||||||||||||||||||||||
HUGO | HGNC:10901 | ||||||||||||||||||||||||
OMIM | 601436 | ||||||||||||||||||||||||
CCDS | CCDS58944 CCDS3915 CCDS3916 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | 6502 | ||||||||||||||||||||||||