Version 5.4
Mus musculus Gene: Mkl1
Summary
InnateDB Gene IDBG-164431.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mkl1
Gene Name MKL (megakaryoblastic leukemia)/myocardin-like 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000042292
Encoded Proteins
IDBP-262093
MKL (megakaryoblastic leukemia)/myocardin-like 1
IDBP-537272
MKL (megakaryoblastic leukemia)/myocardin-like 1
IDBP-542596
MKL (megakaryoblastic leukemia)/myocardin-like 1
IDBP-535113
MKL (megakaryoblastic leukemia)/myocardin-like 1
IDBP-537634
MKL (megakaryoblastic leukemia)/myocardin-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196588:
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:81012281-81190757
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000109579 ENSMUSP00000105207
ENSMUST00000149582 ENSMUSP00000117745
ENSMUST00000134469 ENSMUSP00000119530
ENSMUST00000131235 ENSMUSP00000120116
ENSMUST00000135047 ENSMUSP00000118451
ENSMUST00000138769
ENSMUST00000145779
ENSMUST00000154797
ENSMUST00000123243
ENSMUST00000147921
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005515 protein binding
GO:0043522 leucine zipper domain binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0010735 positive regulation of transcription via serum response element binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051145 smooth muscle cell differentiation
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196588
View Gene Order
ENSBTAG00000002630
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
rhoa_pathway
RhoA signaling pathway
Cross-References
SwissProt
TrEMBL D3YUI2
UniProt Splice Variant
Entrez Gene 223701
UniGene Mm.439814
RefSeq NM_001082536 NM_153049
OMIM
CCDS CCDS37147 CCDS49674
HPRD
IMGT
MGI ID MGI:2384495
MGI Symbol Mkl1
EMBL AC102198 AC141880
GenPept
RNA Seq Atlas 223701

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca