Version 5.4
Mus musculus Gene: Sorbs1
Summary
InnateDB Gene IDBG-164596.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sorbs1
Gene Name sorbin and SH3 domain containing 1
Synonyms 2310065E01Rik; 9530001P15Rik; CAP; mKIAA1296; Sh3d5; SH3P12
Species Mus musculus
Ensembl Gene ENSMUSG00000025006
Encoded Proteins
IDBP-164600
sorbin and SH3 domain containing 1
IDBP-164602
sorbin and SH3 domain containing 1
IDBP-621428
sorbin and SH3 domain containing 1
IDBP-621429
sorbin and SH3 domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095637:
This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:40295049-40402267
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000099467 ENSMUSP00000097066
ENSMUST00000099466 ENSMUSP00000097065
ENSMUST00000165212 ENSMUSP00000126460
ENSMUST00000165469 ENSMUSP00000125768
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0007015 actin filament organization
GO:0008286 insulin receptor signaling pathway
Cellular Component
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005899 insulin receptor complex
GO:0005925 focal adhesion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000095637
View Gene Order
ENSBTAG00000002880
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04910
Insulin signaling pathway pathway
mmu03320
PPAR signaling pathway pathway
mmu04520
Adherens junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa04520
Adherens junction pathway
hsa04910
Insulin signaling pathway pathway
hsa03320
PPAR signaling pathway pathway
INOH
PID NCI
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.210815
RefSeq NM_001034962 NM_001034963 NM_001034964 NM_009166 NM_178362 XM_006526808 XM_006526809 XM_006526810 XM_006526812
OMIM
CCDS CCDS37978 CCDS37979 CCDS37980 CCDS37981
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca